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[二膦酸对渗出和增殖过程的影响]

[The effect of dimephosphon on exudative and proliferative processes].

作者信息

Ziganshina L E, Studentsova I A, Zaikonnikova I V, Ziganshin A U, Popova L G

出版信息

Farmakol Toksikol. 1990 Jan-Feb;53(1):57-9.

PMID:2328804
Abstract

The effects of dimephosphon on the models of inflammation which permitted the separation of the exudative and proliferative phases were studied on rats. The drug effect on the levels of histamine, serotonin and their precursors in blood of healthy rats was also investigated. Dimephosphon was found to exert no inhibitory influence on the proliferative reaction in contrast to the well-known non-steroidal anti-inflammatory drugs. The antihistamine activity of dimephosphon occurring on account of the intensification of histaminopexy was established. It is suggested that the antihistamine activity of dimephosphon should be used for therapeutic purposes.

摘要

在大鼠身上研究了二甲基膦酸对可区分渗出期和增殖期的炎症模型的影响。还研究了该药物对健康大鼠血液中组胺、5-羟色胺及其前体水平的作用。与众所周知的非甾体抗炎药不同,发现二甲基膦酸对增殖反应没有抑制作用。确定了二甲基膦酸由于组胺固定增强而产生的抗组胺活性。建议将二甲基膦酸的抗组胺活性用于治疗目的。

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