Klammer Georg, Betz Michael, Delaloye Barbara, Farshad Mazda, Peter Koch P
Department of Orthopaedics, Uniklinik Balgrist, Zurich, Switzerland.
Department of Radiology, Uniklinik Balgrist, Zurich, Switzerland.
J Knee Surg. 2013 Dec;26 Suppl 1:S67-71. doi: 10.1055/s-0032-1313739. Epub 2012 May 15.
Pigmented villonodular synovitis (PVNS) is a proliferative disease of synovial tissue characterized by lipid-laden macrophages, multinucleated giant cells, and hemosiderin deposits. PVNS presents either in a localized form with minimal rates of recurrence after surgical resection or in a diffuse form with an expansive growth pattern showing formation of osseous erosions and extra-articular manifestation. In the diffuse form high recurrence rates occur as a result of the challenge of achievement of total synovectomy. Typically only one single joint, being the knee in 80% of cases, is involved with diffuse PVNS. Reports of bi- or multiarticular manifestation are at best rare. Here, a case of a 16-year-old girl with bilateral diffuse PVNS of the knee allows discussion of diagnostic and treatment considerations.
色素沉着绒毛结节性滑膜炎（PVNS）是一种滑膜组织的增殖性疾病，其特征为充满脂质的巨噬细胞、多核巨细胞和含铁血黄素沉积。PVNS可表现为局限性，手术切除后复发率极低；也可表现为弥漫性，呈扩张性生长模式，出现骨质侵蚀和关节外表现。由于完全滑膜切除存在挑战，弥漫性PVNS的复发率较高。通常，弥漫性PVNS仅累及一个单一关节，80%的病例为膝关节。双关节或多关节表现的报道极为罕见。在此，一名16岁双侧膝关节弥漫性PVNS女孩的病例有助于探讨诊断和治疗方面的考虑因素。
