Shimbo M, Ohtsuka S, Sakaya S, Sakamoto S, Ikeda H, Sekiguchi S
Hokkaido Red Cross Blood Center, Sapporo, Japan.
Hokkaido Igaku Zasshi. 1990 Jan;65(1):67-73.
In order to investigate the immunogenetic factors associated with hepatitis B virus (HBV) carrier state, the HBe seroconversion and the development of chronic liver disease, HLA typing were performed in 278 asymptomatic HBV carriers (ASC) and 110 patients with chronic B type hepatitis (CH). HLA typing was also performed in 178 vaccinees who had received hepatitis B vaccine. The significantly decreased frequencies of DR1 and DRw13 were found in ASC, CH and non-responders to HB vaccine. This suggests that DR1 and DRw13 may be associated with the elimination of HBV. The frequency of DR4.2 was increased in ASC, but decreased in CH. The seroconversion rate of DR4.2 positive CH as well as ASC was high. Therefore DR4.2 may have relevance to the seroconversion from HBeAg to anti-HBe.
为了研究与乙肝病毒（HBV）携带者状态、HBe血清学转换及慢性肝病发生相关的免疫遗传因素，对278例无症状HBV携带者（ASC）和110例慢性乙型肝炎（CH）患者进行了HLA分型。还对178名接种过乙肝疫苗的受种者进行了HLA分型。在ASC、CH及乙肝疫苗无应答者中发现DR1和DRw13的频率显著降低。这表明DR1和DRw13可能与HBV的清除有关。DR4.2在ASC中的频率升高，但在CH中降低。DR4.2阳性的CH及ASC的血清学转换率较高。因此，DR4.2可能与HBeAg向抗-HBe的血清学转换有关。
