Hsu C H
Department of Psychology, National Taiwan University, Taipei.
Horm Behav. 1990 Mar;24(1):14-9. doi: 10.1016/0018-506x(90)90023-q.
Normal female hamsters display lordosis after testosterone propionate (TP) plus progesterone (P) treatments. Such effect is probably mediated through aromatization of testosterone (T) into estradiol. If so, then an aromatase inhibitor (ATD) or an estrogen antagonist (tamoxifen, TAM) should be able to block the activational effect of T on lordosis. To test this hypothesis, 48 ovariectomized female hamsters were assigned into six groups which, according to treatments received, were ATD + TP, TAM + TP, OIL + TP, ATD + EB (estradiol benzoate), TAM + EB, and OIL + EB groups. The groups received assigned treatments for 2 days and were injected with P on the third day. Five minutes of behavior test was conducted 4 hr after P injection. The OIL + TP, OIL + EB, and ATD + EB groups all had averaged total lordosis duration (TLD) longer than 200 sec. The TLD of the TAM + EB group was only 117 sec. The ATD + TP and TAM + TP groups showed almost no lordosis. The results showed that the estrogen antagonist (TAM) impaired lordosis no matter whether the animals were primed with TP or EB, but the aromatase inhibitor (ATD) blocked lordosis only in TP primed females. It is concluded that the aromatization of T to estrogen is required for testosterone activation of lordosis in female hamsters.
正常雌性仓鼠在接受丙酸睾酮（TP）加孕酮（P）处理后会出现脊柱前凸。这种效应可能是通过睾酮（T）芳香化转化为雌二醇介导的。如果是这样，那么芳香化酶抑制剂（ATD）或雌激素拮抗剂（他莫昔芬，TAM）应该能够阻断T对脊柱前凸的激活作用。为了验证这一假设，将48只去卵巢的雌性仓鼠分为六组，根据接受的处理，分别为ATD + TP组、TAM + TP组、油剂 + TP组、ATD + 雌二醇苯甲酸酯（EB）组、TAM + EB组和油剂 + EB组。这些组接受指定处理2天，并在第三天注射P。在注射P后4小时进行5分钟的行为测试。油剂 + TP组、油剂 + EB组和ATD + EB组的平均总脊柱前凸持续时间（TLD）均超过200秒。TAM + EB组的TLD仅为117秒。ATD + TP组和TAM + TP组几乎没有脊柱前凸表现。结果表明，无论动物是用TP还是EB预处理，雌激素拮抗剂（TAM）都会损害脊柱前凸，但芳香化酶抑制剂（ATD）仅在TP预处理的雌性仓鼠中阻断脊柱前凸。结论是，T向雌激素的芳香化是雌性仓鼠中睾酮激活脊柱前凸所必需的。
