Steel E, Hutchison J B
MRC Unit on the Development and Integration of Behaviour, University of Cambridge, Madingley, United Kingdom.
Horm Behav. 1988 Jun;22(2):252-65. doi: 10.1016/0018-506x(88)90070-0.
This study examines three independent behavioral variables known to be activated by testosterone in the male hamster; namely, the tendency to approach the female, the tendency to leave the female, and the amount of sniffing directed to her. Both intact and testosterone-maintained castrated male hamsters were given the aromatase inhibitor 1,4,6-androstatriene-3,17-dione (ATD) in subcutaneous, Silastic capsules. In intact males, there was an ATD dose-dependent increase in the tendency to leave the female and a decrease in the amount of olfactory investigation. The tendency of the male to approach the female was unaffected. The higher doses of ATD also abolished the ability of males to discriminate between females using vaginal odor cues. These results were confirmed in castrated males whose behavior was maintained at the intact level by testosterone implants. In addition, in both intact and castrated males, estradiol or diethylstilbestrol was able to reverse the behavioral changes induced by ATD. Our results indicate that estrogen produced by aromatization of testosterone activates behavior. We conclude that estrogen, by influencing some, but not all, components of masculine behavior, has a specific role in modulating male-female interactions.
本研究考察了已知在雄性仓鼠中由睾酮激活的三个独立行为变量；即接近雌性的倾向、离开雌性的倾向以及指向雌性的嗅探量。完整的和用睾酮维持的去势雄性仓鼠均通过皮下硅橡胶胶囊给予芳香化酶抑制剂1,4,6 - 雄甾三烯 - 3,17 - 二酮（ATD）。在完整雄性仓鼠中，离开雌性的倾向呈ATD剂量依赖性增加，嗅觉探究量减少。雄性接近雌性的倾向未受影响。较高剂量的ATD还消除了雄性利用阴道气味线索区分雌性的能力。这些结果在通过植入睾酮使其行为维持在完整水平的去势雄性仓鼠中得到证实。此外，在完整和去势雄性仓鼠中，雌二醇或己烯雌酚都能够逆转由ATD诱导的行为变化。我们的结果表明，睾酮芳香化产生的雌激素激活行为。我们得出结论，雌激素通过影响雄性行为的某些但并非全部成分，在调节雌雄互动中具有特定作用。
