视网膜转导素β亚基（Gnb - 1）的基因定位于小鼠4号染色体远端，相关序列定位于小鼠5号和8号染色体。

The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8.

作者信息

Danciger M, Farber D B, Peyser M, Kozak C A

机构信息

Jules Stein Eye Institute, UCLA School of Medicine 90024-1771.

出版信息

Genomics. 1990 Mar;6(3):428-35. doi: 10.1016/0888-7543(90)90472-7.

DOI:10.1016/0888-7543(90)90472-7

PMID:2328987

Abstract

The heterotrimeric G protein transducin releases cGMP-phosphodiesterase from inhibition in retinal rod photoreceptor cells when stimulated by light-activated rhodopsin. As a result the level of cGMP goes down, the rod plasma membrane hyperpolarizes, and the release of neurotransmitter is modified. We have used a bovine cDNA for the beta-subunit of transducin (G beta 1) to map its gene Gnb-1 to distal mouse chromosome 4. This cDNA also identified two other homologous sequences in the mouse genome. One of the sequences was on chromosome 5 which we identified as the locus of Gnb-2, a second G protein beta-subunit gene. The other sequence was on chromosome 8 and is either a pseudogene or an as yet undiscovered third G beta-subunit gene, here termed Gnb-3.

摘要

当受到光激活的视紫红质刺激时，异源三聚体G蛋白转导素会解除对视网膜视杆光感受器细胞中cGMP磷酸二酯酶的抑制。结果，cGMP水平下降，视杆细胞质膜超极化，神经递质的释放发生改变。我们使用了牛转导素β亚基（Gβ1）的cDNA将其基因Gnb-1定位到小鼠4号染色体远端。该cDNA还在小鼠基因组中鉴定出另外两个同源序列。其中一个序列位于5号染色体上，我们将其鉴定为第二个G蛋白β亚基基因Gnb-2的位点。另一个序列位于8号染色体上，要么是一个假基因，要么是一个尚未发现的第三个Gβ亚基基因，这里称为Gnb-3。