环孢素 0.05%滴眼液治疗伴有慢性干眼的 Stevens-Johnson 综合征的疗效。
Efficacy of cyclosporine 0.05% eye drops in Stevens Johnson syndrome with chronic dry eye.
机构信息
Department of Ophthalmology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
出版信息
J Ocul Pharmacol Ther. 2013 Apr;29(3):372-7. doi: 10.1089/jop.2012.0009. Epub 2013 Jan 5.
OBJECTIVE
To evaluate the efficacy of cyclosporine 0.05% (CsA) eye drops in patients with Stevens Johnson syndrome (SJS) who had chronic dry eye.
DESIGN
Prospective noncomparative interventional case series.
METHODS
Thirty cases of SJS patients who developed dry eye defined by symptoms and signs, including the Schirmer I test, the fluorescein clearance test (FCT), and corneal staining (fluorescein and Rose Bengal staining) were treated with CsA 0.05% eye drops twice daily for 6 months. Dry eye symptoms, eye injection, tear break up time (TBUT), and corneal staining were evaluated before and after the treatment at 0, 2, 4, and 6 months. The Shirmer I test and FCT were evaluated at 0 and 6 months.
RESULTS
Seventeen patients (56.67%) completed the study. Eight patients (26.67%) withdrew from the study as a result of intolerable side effects of CsA, which included pain, redness, and eyelid swelling. Five cases were lost in follow up. All 17 cases demonstrated significant improvement in dry eye symptoms, conjunctival injection, corneal staining, Schirmer I test, and FCT (P<0.05).
CONCLUSIONS
CsA 0.05% eye drops might be beneficial in the treatment of chronic dry eye associated with SJS.
目的
评估环孢素 0.05%（CsA）滴眼液治疗史蒂文斯-约翰逊综合征（SJS）患者慢性干眼症的疗效。
设计
前瞻性非对照干预性病例系列研究。
方法
30 例 SJS 患者出现干眼症状和体征，包括 Schirmer I 试验、荧光素清除试验（FCT）和角膜染色（荧光素和孟加拉玫瑰红染色），用 CsA 0.05%滴眼液每天滴眼 2 次，治疗 6 个月。在治疗前、治疗后 0、2、4 和 6 个月评估干眼症状、眼内注射、泪膜破裂时间（TBUT）和角膜染色。在 0 和 6 个月评估 Schirmer I 试验和 FCT。
结果
17 例患者（56.67%）完成了研究。8 例（26.67%）因 CsA 的不良反应（包括疼痛、发红和眼睑肿胀）而退出研究。5 例失访。所有 17 例患者的干眼症状、结膜充血、角膜染色、Schirmer I 试验和 FCT 均有显著改善（P<0.05）。
结论
CsA 0.05%滴眼液可能有益于治疗 SJS 相关的慢性干眼症。
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