Wu Jiao, Wu Yun-tao, Feng Shu-xiu, Meng Heng, Chen Hui
Department of Maternal and Child Health, Huazhong University of Science and Technology, Wuhan, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Nov;33(11):1111-4.
To understand the relationship between negative life events and suicide ideation, and how it was influenced by the mediating effect of depression.
1145 college students from one university were selected using cluster sampling. Both Symptom Check List (SCL-90) and Questionnaire were administered to measure depression and suicide ideation in the past week and on the prevalence of negative life events and related information. Recent negative life events would include physical illness, academic problem, financial problem and interpersonal conflict etc. Multiple logistic regressions were used to identify the mediating effect of depression.
Physical illness (OR = 2.5, P = 0.028), interpersonal conflict (OR = 7.2, P = 0.002) and financial problem (OR = 1.6, P = 0.026) were significantly associated with suicide ideation, but academically-related problems did not seem to be significantly associated with suicide ideation (OR = 1.8, P = 0.090). After adjusted for depression, both physical illness and interpersonal conflicts were not but financial problem remained significantly associated with suicide ideation (OR = 1.7, P = 0.014). Our data showed that depression fully mediated the relationship between physical illness, interpersonal conflict and suicide ideation, but did not mediate the relationship between financial problem and suicide ideation.
Depression played different mediating roles between different negative life events and suicide ideation. The findings from this study might be able to provide some clues for the prevention interventions on college students.
了解负性生活事件与自杀意念之间的关系，以及抑郁的中介作用对其产生的影响。
采用整群抽样法选取某大学1145名大学生。使用症状自评量表（SCL-90）和问卷来测量过去一周内的抑郁、自杀意念以及负性生活事件的发生率和相关信息。近期的负性生活事件包括身体疾病、学业问题、经济问题和人际冲突等。采用多元逻辑回归分析来确定抑郁的中介作用。
身体疾病（OR = 2.5，P = 0.028）、人际冲突（OR = 7.2，P = 0.002）和经济问题（OR = 1.6，P = 0.026）与自杀意念显著相关，但学业相关问题似乎与自杀意念无显著关联（OR = 1.8，P = 0.090）。在对抑郁进行校正后，身体疾病和人际冲突与自杀意念不再相关，但经济问题仍与自杀意念显著相关（OR = 1.7，P = 0.014）。我们的数据表明，抑郁完全中介了身体疾病、人际冲突与自杀意念之间的关系，但未中介经济问题与自杀意念之间的关系。
抑郁在不同的负性生活事件与自杀意念之间发挥了不同的中介作用。本研究结果可能为大学生预防干预提供一些线索。
