Department of Occupational Medicine, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy.
Chemosphere. 2013 Feb;90(7):2077-84. doi: 10.1016/j.chemosphere.2012.10.060. Epub 2013 Jan 3.
This cross-sectional study was conducted to assess the relationship between exposure to cadmium and circulating reproductive hormone levels in urban and rural male workers.
Urinary cadmium, blood cadmium, luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone were obtained from 86 non-smoking traffic policemen and 86 subjects working as roadmen in a rural area. All subjects were monitored to evaluate airborne exposure to cadmium.
The mean value of exposure to cadmium was 1.3 ng m(-3) in traffic policemen, while the mean value was less than 0.5 ng m(-3) in roadmen. The mean concentrations of urinary cadmium (1.4 vs. 0.9 μg g(-1) creatinine; p=0.001), blood cadmium (1.1 vs. 0.7 μg l(-1); p=0.000), FSH (2.6 vs. 3.2 μlU ml(-1); p=0.02) and LH (2.6 vs. 3.1 μlU ml(-1); p=0.03) were significantly different between traffic policemen and roadmen. No differences were found in the mean values of testosterone between the two groups. Multiple linear regression models showed associations between (a) urinary cadmium, airborne cadmium, working life, job category and consumption of water from water supply (b) blood cadmium, airborne cadmium and job category (c) the values of FSH and age, working life, job category, urinary cadmium and blood cadmium (d) the values of LH and both the age and working life.
The above results must be confirmed by further studies, but they indicate the influence of exposure to the cadmium present in urban air on the circulating FSH, even at low doses.
本横断面研究旨在评估城市和农村男性工人接触镉与循环生殖激素水平之间的关系。
从 86 名不吸烟的交通警察和 86 名在农村地区从事道路工作的人员中获得尿镉、血镉、黄体生成素（LH）、卵泡刺激素（FSH）和睾酮。所有受试者均进行监测以评估空气中的镉暴露。
交通警察的镉暴露平均值为 1.3ng m(-3)，而道路工人的平均值小于 0.5ng m(-3)。尿镉（1.4 与 0.9μg g(-1)肌酐；p=0.001）、血镉（1.1 与 0.7μg l(-1)；p=0.000）、FSH（2.6 与 3.2μlU ml(-1)；p=0.02）和 LH（2.6 与 3.1μlU ml(-1)；p=0.03）在交通警察和道路工人之间存在显著差异。两组之间的睾酮平均值没有差异。多元线性回归模型显示，（a）尿镉、空气中的镉、工作年限、职业类别和供水饮用水消费之间存在关联，（b）血镉、空气中的镉和职业类别之间存在关联，（c）FSH 值与年龄、工作年限、职业类别、尿镉和血镉之间存在关联，（d）LH 值与年龄和工作年限之间存在关联。
虽然还需要进一步的研究来证实上述结果，但它们表明，即使在低剂量下，城市空气中存在的镉暴露也会对循环 FSH 产生影响。
