Department of Gastroenterology, Çanakkale Onsekiz Mart University, Turkey.
Arch Med Res. 2013 Jan;44(1):34-8. doi: 10.1016/j.arcmed.2012.11.007. Epub 2013 Jan 3.
Liver fatty acid-binding protein (L-FABP) is a small molecule. The aim of this study was to examine L-FABP levels and to detect its diagnostic value in chronic hepatitis C (CHC).
We studied 22 patients with CHC and 20 healthy control subjects. Patients with persistently elevated serum aminotransferases and positive HCV RNA were included in the study. Patients with CHC underwent percutaneous liver biopsy. Serum level of L-FABP was determined by ELISA method.
Patients with CHC had significantly increased levels of L-FABP compared to controls. A strong correlation between serum L-FABP concentrations and aspartate aminotransferases, alanine aminotransferases, HCV RNA levels and hepatic inflammation was found. When a cut-off value was 29,000 pg/mL for L-FABP, sensitivity and specificity were 75 and 100%, respectively. Positive and negative predictive values for L-FABP were 100 and 78%, respectively.
Serum L-FABP is used as a new diagnostic marker to detect liver injury.
肝型脂肪酸结合蛋白（L-FABP）是一种小分子。本研究旨在检测 L-FABP 水平，并探讨其在慢性丙型肝炎（CHC）中的诊断价值。
我们研究了 22 例 CHC 患者和 20 例健康对照者。纳入研究的患者为持续血清转氨酶升高和 HCV RNA 阳性的患者。CHC 患者接受了经皮肝活检。采用 ELISA 法检测血清 L-FABP 水平。
与对照组相比，CHC 患者的 L-FABP 水平显著升高。发现血清 L-FABP 浓度与天冬氨酸转氨酶、丙氨酸转氨酶、HCV RNA 水平和肝炎症之间存在很强的相关性。当 L-FABP 的截断值为 29,000 pg/mL 时，其敏感性和特异性分别为 75%和 100%。L-FABP 的阳性和阴性预测值分别为 100%和 78%。
血清 L-FABP 可作为一种新的诊断标志物，用于检测肝损伤。
