Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13005 Ciudad Real, Spain.
Vaccine. 2013 Feb 6;31(8):1187-96. doi: 10.1016/j.vaccine.2012.12.073. Epub 2013 Jan 3.
Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and thus their control is important for the eradication of vector-borne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common vector. Recent results have suggested that subolesin/akirin (SUB/AKR) is good candidate antigens for the control of arthropod vector infestations. Here we describe the comparative effect of vaccination with SUB, AKR and Q38 and Q41 chimeras containing SUB/AKR conserved protective epitopes on tick, mosquitoes and sand flies vector mortality, molting, oviposition and/or fertility. We demonstrated that SUB vaccination had the highest efficacy (E) across all vector species (54-92%), Q41 vaccination had the highest vaccine E in mosquitoes (99%) by reducing female survival and fertility, and Q38 vaccination had the highest effect on reducing mosquito (28%) and sand fly (26%) oviposition. The effect of vaccination on different developmental processes in several important arthropod vectors encourages the development of SUB/AKR universal vaccines for the control of multiple vector infestations and reduction of VBD.
节肢动物媒介传播的疾病（如蚊子、蜱虫和沙蝇）极大地影响了人类和动物的健康，因此控制这些疾病对于消除媒介传播疾病（VBD）非常重要。疫苗接种是一种环保的媒介控制替代方法，它可以通过针对其共同媒介来控制几种 VBD。最近的研究结果表明，亚油酸/akirin（SUB/AKR）是控制节肢动物媒介侵扰的良好候选抗原。在这里，我们描述了接种 SUB、AKR 和含有 SUB/AKR 保守保护表位的 Q38 和 Q41 嵌合体对蜱、蚊子和沙蝇媒介死亡率、蜕皮、产卵和/或生育能力的比较效果。我们证明了 SUB 接种在所有媒介物种中的有效性（E）最高（54-92%），Q41 接种通过降低雌性存活率和生育能力在蚊子中具有最高的疫苗 E（99%），Q38 接种对减少蚊子（28%）和沙蝇（26%）产卵的效果最高。疫苗接种对几种重要节肢动物媒介的不同发育过程的影响鼓励开发 SUB/AKR 通用疫苗，以控制多种媒介感染和减少 VBD。
