Hao Xia, Xia Lingzi, Qu Ruoyi, Yang Xianglin, Jiang Min, Zhou Baosen
China Medical University, Shenyang, China.
Fam Cancer. 2018 Jul;17(3):459-468. doi: 10.1007/s10689-017-0056-0.
The rapidly increasing of cancer risk nationwide and worldwide has threatened human health and caused the changes of disease and death spectrum. MicroRNA (MiRNA) as cancer biomarker on susceptibility has enjoyed a high level of concern. This article will discuss the association between miR-146 rs2910164 polymorphism and cancer susceptibility in 38 independent case-control studies from 34905 individuals. The 38 case-control studies which were searched from PubMed were used for conducting a meta-analysis. There were 14670 cases and 20235 controls. ORs and 95% CIs were used for reflecting the strength of association between miR-146a rs2910164 polymorphism and cancer susceptibility. Subgroup analysis based on the cancer type, ethnicity and study designs. All analysis were performed by using the Stata 11.0 software. MiR-146a rs2910164 polymorphism and overall cancer susceptibility were significantly uncorrelated in all genetic models. In the subgroup analysis for cancer types, miR-146a rs2910164 polymorphism was associated with the susceptibility of lung cancer (CC vs. GG: OR 1.275, 95% CI 1.117-1.455 (P = 0.000); CC + CG vs. GG: OR 1.166, 95% CI 1.052-1.293 (P = 0.003); CC vs. CG + GG: OR 1.239, 95% CI 1.116-1.375 (P = 0.000); C vs. G OR 1.151, 95% CI 1.080-1.227 (P = 0.000)) and nasopharyngeal carcinoma (CC vs. GG: OR 1.713, 95% CI 1.183-2.479 (P = 0.004); CC vs. CG + GG: OR 1.672, 95% CI 1.330-2.103 (P = 0.000); C vs. G: OR 1.400, 95% CI 1.181-1.659 (P = 0.000)), but it was not associated with hepatocellular carcinoma and gastric cancer. However, in the other subgroup analysis by ethnicity and study designs, no significant associations were found. MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma.
在全国乃至全球范围内，癌症风险的迅速增加威胁着人类健康，并导致了疾病和死亡谱的变化。微小RNA（MiRNA）作为癌症易感性的生物标志物受到了高度关注。本文将探讨来自34905名个体的38项独立病例对照研究中miR - 146 rs2910164多态性与癌症易感性之间的关联。从PubMed检索到的38项病例对照研究用于进行荟萃分析。其中有14670例病例和20235例对照。比值比（ORs）和95%可信区间（CIs）用于反映miR - 146a rs2910164多态性与癌症易感性之间关联的强度。基于癌症类型、种族和研究设计进行亚组分析。所有分析均使用Stata 11.0软件进行。在所有遗传模型中，miR - 146a rs2910164多态性与总体癌症易感性显著不相关。在癌症类型的亚组分析中，miR - 146a rs2910164多态性与肺癌易感性相关（CC与GG：OR 1.275，95% CI 1.117 - 1.455（P = 0.000）；CC + CG与GG：OR 1.166，95% CI 1.052 - 1.293（P = 0.003）；CC与CG + GG：OR 1.239，95% CI 1.116 - 1.375（P = 0.000）；C与G OR 1.151，95% CI 1.080 - 1.227（P = 0.000））以及鼻咽癌易感性相关（CC与GG：OR 1.713，95% CI 1.183 - 2.479（P = 0.004）；CC与CG + GG：OR 1.672，95% CI 1.330 - 2.103（P = 0.000）；C与G：OR 1.400，95% CI 1.181 - 1.659（P = 0.000）），但与肝细胞癌和胃癌无关。然而，在按种族和研究设计进行的其他亚组分析中，未发现显著关联。miR - 146a rs2910164多态性可能与肺癌和鼻咽癌的易感性相关。
