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一名腹痛患者黑色素瘤大网膜转移的病例报告。

Case report of an omental metastasis of melanoma in a patient with abdominal pain.

作者信息

Sabah Jonathan, Marouk Alexis, Vallois Louis, Akladios Chérif

机构信息

Gynecologic Surgery Department, University Hospital of Strasbourg, Strasbourg, France.

Emergency Department, Public Assistance of Paris Hospitals, Paris, France.

出版信息

Int J Surg Case Rep. 2025 Feb;127:110988. doi: 10.1016/j.ijscr.2025.110988. Epub 2025 Jan 30.

Abstract

INTRODUCTION

Choroidal melanoma primarily metastasizes to the liver, but rare sites like the omentum can also be affected, making this case educational due to its uncommon presentation. The decision to pursue surgical treatment for metastatic melanoma remains controversial.

CASE PRESENTATION

A woman in her 60s, with a history of a stable choroidal nevus, experienced rapid lesion growth, leading to enucleation and radiotherapy. Two years later, she developed severe epigastric pain. Imaging revealed peritoneal nodules, and histopathology confirmed metastatic choroidal melanoma. Molecular analysis identified a GNAQ G48L mutation.

DISCUSSION

Omental metastasis in choroidal melanoma is rare, and while surgery is uncommon for metastatic melanoma, it was performed to alleviate symptoms and improve functionality. Following omentectomy and immunotherapy, her condition remained stable for two years.

CONCLUSION

This case emphasizes the importance of recognizing atypical metastatic sites in melanoma. Surgical intervention, though rare, can be beneficial for symptom relief in selected cases, improving outcomes when combined with targeted treatments.

摘要

引言

脉络膜黑色素瘤主要转移至肝脏,但像大网膜这样的罕见部位也可能受累,因其不常见的表现,此病例具有教学意义。对于转移性黑色素瘤是否进行手术治疗的决定仍存在争议。

病例介绍

一名60多岁的女性,有稳定的脉络膜痣病史,病变迅速生长,导致眼球摘除和放疗。两年后,她出现严重的上腹部疼痛。影像学检查发现腹膜结节,组织病理学证实为转移性脉络膜黑色素瘤。分子分析确定存在GNAQ G48L突变。

讨论

脉络膜黑色素瘤的大网膜转移罕见,虽然转移性黑色素瘤很少进行手术,但为缓解症状和改善功能还是进行了手术。在网膜切除和免疫治疗后,她的病情稳定了两年。

结论

本病例强调了认识黑色素瘤非典型转移部位的重要性。手术干预虽然罕见,但在某些选定病例中可有助于缓解症状,与靶向治疗联合使用时可改善预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb35/11834068/c3983291cad8/gr1.jpg

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