Ganapathy K, Kurup P G G, Murali V, Muthukumaran M, Bhuvaneshwari N, Velmurugan J
Department of Radiotherapy, Apollo Speciality Hospital, Chennai, India.
J Med Phys. 2012 Oct;37(4):214-8. doi: 10.4103/0971-6203.103607.
Total body irradiation (TBI) is a special radiotherapy technique, administered prior to bone marrow transplantation. Due to the complex nature of the treatment setup, in vivo dosimetry for TBI is mandatory to ensure proper delivery of the intended radiation dose throughout the body. Lithium fluoride (LiF) TLD-100 chips are used for the TBI in vivo dosimetry. Results obtained from the in vivo dosimetry of 20 patients are analyzed. Results obtained from forehead, abdomen, pelvis, and mediastinum showed a similar pattern with the average measured dose from 96 to 97% of the prescription dose. Extremities and chest received a dose greater than the prescription dose in many instances (more than 20% of measurements). Homogeneous dose delivery to the whole body is checked by calculating the mean dose with standard deviation for each fraction. Reasons for the difference between prescription dose and measured dose for each site are discussed. Dose homogeneity within ±10% is achieved using our in-house TBI protocol.
全身照射（TBI）是一种特殊的放射治疗技术，在骨髓移植前进行。由于治疗设置的复杂性，TBI的体内剂量测定对于确保在全身正确输送预期的辐射剂量是必不可少的。氟化锂（LiF）TLD - 100芯片用于TBI的体内剂量测定。对20例患者的体内剂量测定结果进行了分析。从前额、腹部、骨盆和纵隔获得的结果显示出相似的模式，平均测量剂量为处方剂量的96%至97%。在许多情况下，四肢和胸部接受的剂量大于处方剂量（超过20%的测量值）。通过计算每个分次的平均剂量及其标准差来检查全身剂量的均匀性。讨论了每个部位处方剂量与测量剂量之间差异的原因。使用我们内部的TBI方案可实现±10%以内的剂量均匀性。
