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应用 GafchromicTM EBT3 胶片进行患者剂量分析:全皮肤电子治疗中四种双野技术的回顾性研究。

Patient Dose Analysis Using GafchromicTM EBT3 Film: A Retrospective Study with a Four Dual-Field Technique in Total Skin Electron Therapy.

机构信息

Department of Radiation Oncology, Apollo cancer Hospitals, Chennai, India.

School of Advanced Sciences, Vellore Institute of Technology, Vellore, India.

出版信息

Asian Pac J Cancer Prev. 2023 Jul 1;24(7):2505-2513. doi: 10.31557/APJCP.2023.24.7.2505.

Abstract

OBJECTIVE

The Six dual-field is the most commonly used treatment technique in total skin electron therapy (TSET). Because of the prolonged treatment period, the patient may experience discomfort, and routine radiotherapy treatments may be affected. This reflects the idea of using a modified technique in TSET. The study aims to report our experience with the four dual-field technique and review the in-vivo dosimetry using gafchromic film.

MATERIALS AND METHODS

The in-vivo dosimetry reports using gafchromic EBT-3 films of 12 patients who received TSET with the four dual-field techniques in our hospital were analysed in this study. The dosimetric parameter including percentage depth dose, dose homogeneity, flatness and symmetry were analysed in this study.

RESULTS AND DISCUSSION

For all the patients, the mean dose to the skin was close to the prescription dose, and it was within 10% (99.3%-103%) of the prescription dose. The standard deviation was observed between 5.8 and 12.4 cGy. According to international standards, all of the measured dosimetric parameters were within the acceptable limit and thereby validating our technique.  The in-vivo dosimetry study using radiochromic film in TSET is relatively uncommon. So, based on our results, gafchromic films are a viable choice. The objective of our four dual-field techniques is to reduce the overall treatment time on the machine, whereas our study shows a time reduction when compared to regular techniques, which aids in the smooth operation of daily routines.

CONCLUSION

The preliminary results of this novel modified technique in TSET demonstrated favourable effectiveness with minimal skin toxicity. This four dual-field technique is simple and easy to implement. Comparatively, this study shows the dose homogeneity of ±10% and better dose in the underdose areas proving the reliability and homogeneity of four-dual field technique.

摘要

目的

在全身电子束照射(TSET)中,六野双靶是最常用的治疗技术。由于治疗时间延长,患者可能会感到不适,常规放疗可能会受到影响。这反映了在 TSET 中使用改良技术的理念。本研究旨在报告我们使用四野双靶技术的经验,并回顾使用 Gafchromic 胶片进行的体内剂量学。

材料和方法

本研究分析了我院 12 例接受四野双靶 TSET 治疗的患者的 Gafchromic EBT-3 胶片体内剂量学报告。分析了剂量学参数,包括百分深度剂量、剂量均匀性、平坦度和对称性。

结果和讨论

对于所有患者,皮肤的平均剂量接近处方剂量,在处方剂量的 10%(99.3%-103%)范围内。标准偏差为 5.8 至 12.4 cGy。根据国际标准,所有测量的剂量学参数均在可接受范围内,从而验证了我们的技术。在 TSET 中使用放射性染色胶片进行体内剂量学研究相对较少。因此,根据我们的结果,Gafchromic 胶片是一种可行的选择。我们的四野双靶技术的目的是减少机器上的整体治疗时间,而我们的研究显示与常规技术相比,治疗时间有所缩短,这有助于日常工作的顺利进行。

结论

TSET 中这项新的改良技术的初步结果显示出良好的效果,皮肤毒性最小。该四野双靶技术简单易用。相比之下,本研究显示剂量均匀性为±10%,并且在低剂量区域的剂量更好,证明了四野双靶技术的可靠性和均匀性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a78/10676495/db511c1ed232/APJCP-24-2505-g001.jpg

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