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一种磷脂酰胆碱透明质酸壳聚糖纳米纤维复合物，可实现快速皮肤重塑和焕新外观。

A phosphatidylcholine hyaluronic acid chitin-nanofibrils complex for a fast skin remodeling and a rejuvenating look.

机构信息

Department of Applied Cosmetic Dermatology, University of Naples Federico II, Naples, Italy.

出版信息

Clin Cosmet Investig Dermatol. 2012;5:213-20. doi: 10.2147/CCID.S29664. Epub 2012 Dec 20.

DOI:10.2147/CCID.S29664
PMID:23293530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3534392/
Abstract

BACKGROUND

The reduction of mortality worldwide has led older individuals to seek intervention modalities to improve their appearance and reverse signs of aging.

OBJECTIVE

We formulated a medical device as innovative block-polymer nanoparticles based on phosphatidylcholine, hyaluronan, and chitin nanofibrils entrapping amino acids, vitamins, and melatonin.

METHODS

Viability and collagen synthesis were controlled on fibroblasts ex vivo culture while adenosine triphosphate production was evaluated on keratinocytes culture. Subjective and objective evaluations were performed in vivo on selected volunteer patients.

RESULTS

In accordance with our previous studies, both the in vitro and in vivo obtained results demonstrate the efficacy of the injected block-polymer nanoparticles in reducing skin wrinkling and ameliorating the signs of aging.

摘要

背景

全球死亡率的降低促使老年人寻求干预手段，以改善容貌并逆转衰老迹象。

目的

我们开发了一种基于磷脂酰胆碱、透明质酸和壳聚糖纳米纤维的嵌氨基酸、维生素和褪黑素的创新型嵌段聚合物纳米粒子作为医疗器械。

方法

在体外纤维母细胞培养中控制细胞活力和胶原蛋白合成，在角质形成细胞培养中评估三磷酸腺苷的产生。在选定的志愿者患者中进行体内的主观和客观评估。

结果

根据我们之前的研究，体外和体内获得的结果均表明注射用嵌段聚合物纳米粒子在减少皮肤皱纹和改善衰老迹象方面的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/19d17bd1a623/ccid-5-213f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/b7f5c2ced579/ccid-5-213f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/127c9f1da4af/ccid-5-213f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/b8957e247d41/ccid-5-213f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/2651add10773/ccid-5-213f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/84ad2c7cc7f2/ccid-5-213f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/19d17bd1a623/ccid-5-213f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/b7f5c2ced579/ccid-5-213f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/127c9f1da4af/ccid-5-213f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/b8957e247d41/ccid-5-213f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/2651add10773/ccid-5-213f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/84ad2c7cc7f2/ccid-5-213f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfbe/3534392/19d17bd1a623/ccid-5-213f6.jpg

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本文引用的文献

1
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J Nutr Health Aging. 2012 Mar;16(3):242-5. doi: 10.1007/s12603-011-0358-0.
2
Adverse reactions to injectable soft tissue fillers.注射用软组织填充剂的不良反应。
J Am Acad Dermatol. 2011 Jan;64(1):1-34; quiz 35-6. doi: 10.1016/j.jaad.2010.02.064.
3
Chitin nanofibrils for advanced cosmeceuticals.用于高级药妆品的几丁质纳米纤维。
磷脂酰胆碱通过 DAF-16 延长寿命并降低. 中的淀粉样β诱导的毒性。
Oxid Med Cell Longev. 2019 Jul 11;2019:2860642. doi: 10.1155/2019/2860642. eCollection 2019.
4
Chitin and Chitosans: Characteristics, Eco-Friendly Processes, and Applications in Cosmetic Science.壳聚糖及其特性、环保工艺以及在化妆品科学中的应用。
Mar Drugs. 2019 Jun 21;17(6):369. doi: 10.3390/md17060369.
5
Chitin and Chitosan: Production and Application of Versatile Biomedical Nanomaterials.几丁质与壳聚糖：多功能生物医学纳米材料的生产与应用
Int J Adv Res (Indore). 2016 Mar;4(3):411-427. Epub 2016 Mar 1.
6
Hyaluronan-phosphatidylethanolamine polymers form pericellular coats on keratinocytes and promote basal keratinocyte proliferation.透明质酸 - 磷脂酰乙醇胺聚合物在角质形成细胞上形成细胞周被膜，并促进基底角质形成细胞增殖。
Biomed Res Int. 2014;2014:727459. doi: 10.1155/2014/727459. Epub 2014 Sep 9.
Clin Dermatol. 2008 Jul-Aug;26(4):334-40. doi: 10.1016/j.clindermatol.2008.01.003.
4
The filaggrin story: novel insights into skin-barrier function and disease.丝聚合蛋白的故事：对皮肤屏障功能和疾病的新见解。
Trends Mol Med. 2008 Jan;14(1):20-7. doi: 10.1016/j.molmed.2007.10.006. Epub 2007 Dec 18.
5
Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences.补充肌酸可使线粒体DNA的诱变作用以及功能后果恢复正常。
J Invest Dermatol. 2005 Aug;125(2):213-20. doi: 10.1111/j.0022-202X.2005.23806.x.
6
Moisturization and skin barrier function.保湿与皮肤屏障功能。
Dermatol Ther. 2004;17 Suppl 1:43-8. doi: 10.1111/j.1396-0296.2004.04s1005.x.
7
The mitochondrial theory of aging: dead or alive?衰老的线粒体理论：是死是活？
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8
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Dermatol Surg. 2003 Jun;29(6):588-95. doi: 10.1046/j.1524-4725.2003.29150.x.
9
Age-related changes in vascular adrenergic signaling: clinical and mechanistic implications.血管肾上腺素能信号的年龄相关变化：临床及机制意义
Ageing Res Rev. 2003 Apr;2(2):169-90. doi: 10.1016/s1568-1637(02)00063-6.
10
Structural changes that occur during normal aging of primate cerebral hemispheres.灵长类动物大脑半球正常衰老过程中发生的结构变化。
Neurosci Biobehav Rev. 2002 Nov;26(7):733-41. doi: 10.1016/s0149-7634(02)00060-x.