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几丁质纳米原纤维-纳米木质素复合物作为用于皮肤接触应用的功能分子载体

Chitin Nanofibril-Nanolignin Complexes as Carriers of Functional Molecules for Skin Contact Applications.

作者信息

Coltelli Maria-Beatrice, Morganti Pierfrancesco, Castelvetro Valter, Lazzeri Andrea, Danti Serena, Benjelloun-Mlayah Bouchra, Gagliardini Alessandro, Fusco Alessandra, Donnarumma Giovanna

机构信息

Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), 50121 Florence, Italy.

Department of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy.

出版信息

Nanomaterials (Basel). 2022 Apr 11;12(8):1295. doi: 10.3390/nano12081295.

DOI:10.3390/nano12081295
PMID:35458003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9029034/
Abstract

Chitin nanofibrils (CN) and nanolignin (NL) were used to embed active molecules, such as vitamin E, sodium ascorbyl phosphate, lutein, nicotinamide and glycyrrhetinic acid (derived from licorice), in the design of antimicrobial, anti-inflammatory and antioxidant nanostructured chitin nanofibrils-nanolignin (CN-NL) complexes for skin contact products, thus forming CN-NL/M complexes, where M indicates the embedded functional molecule. Nano-silver was also embedded in CN-NL complexes or on chitin nanofibrils to exploit its well-known antimicrobial activity. A powdery product suitable for application was finally obtained by spray-drying the complexes co-formulated with poly(ethylene glycol). The structure and morphology of the complexes was studied using infrared spectroscopy and field emission scanning electron microscopy, while their thermal stability was investigated via thermo-gravimetry. The latter provided criteria for evaluating the suitability of the obtained complexes for subsequent demanding industrial processing, such as, for instance, incorporation into bio-based thermoplastic polymers through conventional melt extrusion. In vitro tests were carried out at different concentrations to assess skin compatibility. The obtained results provided a physical-chemical, morphological and cytocompatibility knowledge platform for the correct selection and further development of such nanomaterials, allowing them to be applied in different products. In particular, chitin nanofibrils and the CN-NL complex containing glycyrrhetinic acid can combine excellent thermal stability and skin compatibility to provide a nanostructured system potentially suitable for industrial applications.

摘要

几丁质纳米纤维（CN）和纳米木质素（NL）被用于包埋活性分子，如维生素E、抗坏血酸钠磷酸酯、叶黄素、烟酰胺和甘草次酸（源自甘草），用于设计用于皮肤接触产品的抗菌、抗炎和抗氧化纳米结构几丁质纳米纤维 - 纳米木质素（CN - NL）复合物，从而形成CN - NL/M复合物，其中M表示包埋的功能分子。纳米银也被包埋在CN - NL复合物中或几丁质纳米纤维上，以利用其众所周知的抗菌活性。最后通过喷雾干燥与聚乙二醇共配制的复合物获得了适合应用的粉末状产品。使用红外光谱和场发射扫描电子显微镜研究了复合物的结构和形态，同时通过热重分析研究了它们的热稳定性。后者为评估所得复合物对于后续苛刻工业加工（例如通过传统熔融挤出掺入生物基热塑性聚合物）的适用性提供了标准。在不同浓度下进行了体外测试以评估皮肤相容性。所得结果为正确选择和进一步开发此类纳米材料提供了物理化学、形态学和细胞相容性知识平台，使它们能够应用于不同产品。特别是，几丁质纳米纤维和含有甘草次酸的CN - NL复合物可以兼具优异的热稳定性和皮肤相容性，从而提供一种潜在适用于工业应用的纳米结构体系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/bd3b5cc3bd93/nanomaterials-12-01295-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/2051203d64f0/nanomaterials-12-01295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/cc0f644dae34/nanomaterials-12-01295-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/78ad40c06fd3/nanomaterials-12-01295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/d3c40230d25b/nanomaterials-12-01295-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/b94550e8be20/nanomaterials-12-01295-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/7b56b41a84dd/nanomaterials-12-01295-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/aa0814d9d0ff/nanomaterials-12-01295-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/f5dc6cdb3ce4/nanomaterials-12-01295-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/bd3b5cc3bd93/nanomaterials-12-01295-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/09baf0eb5427/nanomaterials-12-01295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/efed5cde9f38/nanomaterials-12-01295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/2051203d64f0/nanomaterials-12-01295-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/cc0f644dae34/nanomaterials-12-01295-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/78ad40c06fd3/nanomaterials-12-01295-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/d3c40230d25b/nanomaterials-12-01295-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/b94550e8be20/nanomaterials-12-01295-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/7b56b41a84dd/nanomaterials-12-01295-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/aa0814d9d0ff/nanomaterials-12-01295-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/f5dc6cdb3ce4/nanomaterials-12-01295-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af47/9029034/bd3b5cc3bd93/nanomaterials-12-01295-g011.jpg

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