Clugnet M C, LeDoux J E, Morrison S F
Center for Neural Science, New York University, New York 10003.
J Neurosci. 1990 Apr;10(4):1055-61. doi: 10.1523/JNEUROSCI.10-04-01055.1990.
Unit activity was recorded from cells and cell clusters in the amygdala and striatum in response to electrical stimulation of the medial geniculate body (MGB) in rats anesthetized with chloral hydrate. Responses were mostly excitatory and were evoked against a relatively silent background (i.e., the units seldom fired between stimuli). The shortest latency responses were recorded in the caudate putamen (CPU), lateral amygdaloid nucleus (AL), and amygdalostriatal transition area (AST). Longer latency responses were obtained from neurons in the basolateral (ABL), basomedial (ABM), and central (ACE) nuclei of the amygdala. Moreover, while responses were evoked in AL, AST, and CPU with 300-500 microA stimuli delivered once every 10 sec, more intense and higher-frequency stimuli were required to obtain responses in ABL, ABM, and ACE. These findings are consistent with anatomical tracing studies showing that AL, AST, and CPU receive direct projections from the MGB and related acoustic processing areas of the thalamus but that ACE, ABL, and ABM do not.
在用氯醛水合麻醉的大鼠中，记录了杏仁核和纹状体中细胞及细胞簇的单位活动，以响应内侧膝状体（MGB）的电刺激。反应大多是兴奋性的，且是在相对安静的背景下诱发的（即单位在刺激之间很少放电）。最短潜伏期反应记录于尾壳核（CPU）、外侧杏仁核（AL）和杏仁核纹状体过渡区（AST）。较长潜伏期反应则来自杏仁核基底外侧（ABL）、基底内侧（ABM）和中央（ACE）核的神经元。此外，虽然以每10秒一次的300 - 500微安刺激在AL、AST和CPU中诱发了反应，但在ABL、ABM和ACE中获得反应则需要更强和更高频率的刺激。这些发现与解剖追踪研究一致，该研究表明AL、AST和CPU接受来自MGB及丘脑相关听觉处理区域的直接投射，但ACE、ABL和ABM则不然。
