Department of Neurology, University of Pecs, Pecs, Hungary.
Eur J Neurol. 2013 Nov;20(11):1492-5. doi: 10.1111/ene.12072. Epub 2013 Jan 7.
Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity.
Antibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC).
Thirty-seven percentages of patients with AQP4-seropositive NMO/NMO-SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (P < 0.01, respectively). Antibodies were most common (46%) in AQP4-seropositive myelitis (P = 0.01 versus HS, P = 0.05 versus MS). Anti-gliadin and ASCA were more frequent in the AQP4-seropositive NMO-spectrum compared to controls (P = 0.01 and P < 0.05, respectively).
Antibody responses against gastrointestinal antigens are common in MS and AQP4-seropositive NMO/NMO-SD, especially in longitudinally extensive myelitis.
针对胃肠道抗原的抗体可能表明胃肠道中微生物群和免疫反应发生了改变。最近的实验数据表明，胃肠道免疫反应与中枢神经系统自身免疫之间存在关联。
在 45 例水通道蛋白 4（AQP4）阳性视神经脊髓炎（NMO）和 NMO 谱系疾病（NMO/NMO-SD）、17 例 AQP4 阴性 NMO、85 例临床确诊多发性硬化症（MS）和 48 例健康对照者（HC）的血清中筛查了针对麦胶蛋白、组织转谷氨酰胺酶（tTG）、内因子（IF）、壁细胞（PC）和酿酒酵母（ASCA）的抗体。
AQP4 阳性 NMO/NMO-SD 患者中有 37%和 MS 患者中有 28%至少有一种特定抗体，而 HC 患者中仅有 8%（分别为 P < 0.01）。在 AQP4 阳性脊髓炎患者中抗体最为常见（46%）（P = 0.01 对比 HS，P = 0.05 对比 MS）。与对照组相比，AQP4 阳性 NMO 谱中抗麦胶蛋白和 ASCA 更为常见（P = 0.01 和 P < 0.05）。
针对胃肠道抗原的抗体反应在 MS 和 AQP4 阳性 NMO/NMO-SD 中很常见，尤其是在长节段性脊髓炎中。
