Laboratories of Comparative Animal Medicine, Tokyo, Japan.
J Dermatol. 2013 Mar;40(3):193-200. doi: 10.1111/1346-8138.12055. Epub 2013 Jan 7.
Drinking water is an important nutrient for human health. The mineral ingredients included in drinking water may affect the physical condition of people. Various kinds of natural water are in circulation as bottled water in developed countries; however, its influence on clinical conditions of patients with certain diseases has not been fully evaluated. In this study, effects of the natural groundwater from Jeju Island on clinical symptoms and skin barrier function in atopic dermatitis (AD) were evaluated. NC/Tnd mice, a model for human AD, with moderate to severe dermatitis were used. Mice were given different natural groundwater or tap water for 8 weeks from 4 weeks of age. Clinical skin severity scores were recorded every week. Scratching analysis and measurement of transepidermal water loss were performed every other week. The pathological condition of the dorsal skin was evaluated histologically. Real-time polymerase chain reaction analysis was performed for cytokine expression in the affected skin. The epidermal hyperplasia and allergic inflammation were reduced in atopic mice supplied with Jeju groundwater when compared to those supplied with tap water or other kinds of natural groundwater. The increase in scratching behavior with the aggravation of clinical severity of dermatitis was favorably controlled. Moreover, transepidermal water loss that reflects skin barrier function was recovered. The early inflammation and hypersensitivity in the atopic skin was alleviated in mice supplied with Jeju groundwater, suggesting its profitable potential on the daily care of patients with skin troubles including AD.
饮用水是人类健康的重要营养物质。饮用水中包含的矿物质成分可能会影响人体的身体状况。在发达国家，各种天然水以瓶装水的形式循环；然而，其对某些疾病患者临床状况的影响尚未得到充分评估。在这项研究中，评估了来自济州岛的天然地下水对特应性皮炎（AD）患者临床症状和皮肤屏障功能的影响。使用 NC/Tnd 小鼠，一种中度至重度皮炎的人类 AD 模型。从 4 周龄开始，将小鼠分别用不同的天然地下水或自来水喂养 8 周。每周记录临床皮肤严重程度评分。每两周进行一次搔抓分析和经皮水分丢失测量。评估背部皮肤的病理状况。对受影响皮肤中的细胞因子表达进行实时聚合酶链反应分析。与用自来水或其他种类的天然地下水喂养的小鼠相比，用济州地下水喂养的特应性小鼠的表皮增生和过敏炎症减少。搔抓行为随着皮炎临床严重程度的加重而增加，也得到了良好的控制。此外，反映皮肤屏障功能的经皮水分丢失也得到了恢复。用济州地下水喂养的小鼠，特应性皮肤的早期炎症和过敏反应得到缓解，这表明其对包括 AD 在内的皮肤问题患者的日常护理具有潜在的益处。
