Tanaka Akane, Matsuda Akira, Jung Kyungsook, Jang Hyosun, Ahn Ginnae, Ishizaka Saori, Amagai Yosuke, Oida Kumiko, Arkwright Peter D, Matsuda Hiroshi
Comparative Animal Medicine and Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, 183-8509 Fuchu, Tokyo, Japan.
Acta Derm Venereol. 2015 Sep;95(7):787-91. doi: 10.2340/00015555-2083.
Mineral ions in tap water react with fatty acids in soap, leading to the formation of insoluble precipitate (metallic soap) on skin during washing. We hypothesised that metallic soap might negatively alter skin conditions. Application of metallic soap onto the skin of NC/Tnd mice with allergic dermatitis further induced inflammation with elevation of plasma immunoglobulin E and proinflammatory cytokine expression. Pruritus and dryness were ameliorated when the back of mice was washed with soap in Ca2+- and Mg2+-free ultra-pure soft water (UPSW). Washing in UPSW, but not tap water, also protected the skin of healthy volunteers from the soap deposition. Furthermore, 4 weeks of showering with UPSW reduced dryness and pruritus of human subjects with dry skin. Washing with UPSW may be therapeutically beneficial in patients with skin troubles.
自来水中的矿物质离子与肥皂中的脂肪酸发生反应，导致在洗涤过程中皮肤表面形成不溶性沉淀（金属皂）。我们推测金属皂可能会对皮肤状况产生负面影响。将金属皂涂抹在患有过敏性皮炎的NC/Tnd小鼠皮肤上，会进一步引发炎症，导致血浆免疫球蛋白E升高和促炎细胞因子表达增加。当用不含Ca2+和Mg2+的超纯软水（UPSW）给小鼠背部洗澡时，瘙痒和干燥症状得到缓解。用UPSW而非自来水洗澡，也能保护健康志愿者的皮肤免受肥皂沉积的影响。此外，用UPSW淋浴4周可减轻干性皮肤受试者的皮肤干燥和瘙痒症状。用UPSW洗澡可能对有皮肤问题的患者具有治疗益处。
