对暴露于氟比洛芬的虹膜进行乙酰胆碱前房冲洗的评估。

Evaluation of flurbiprofen-exposed irises to acetylcholine anterior chamber irrigation.

作者信息

Ozog M F, Zimm J L, Park R, Fisher S, Fort C, McDonald J E

机构信息

Loyola University, Stritch School of Medicine, Maywood, Illinois 60153.

出版信息

J Cataract Refract Surg. 1990 Mar;16(2):226-9. doi: 10.1016/s0886-3350(13)80735-3.

DOI:10.1016/s0886-3350(13)80735-3

PMID:2329482

Abstract

Flurbiprofen (Ocufen), an antiprostaglandin, has been introduced into cataract surgery. It is used to prevent intraoperative miosis by blocking inflammatory mediator formation. Ocufen has been noted to diminish the controlled miosis produced by using acetylcholine in the operative period. This study evaluated the pupillary response to acetylcholine after it had been exposed to Ocufen. This was done using a control versus a study eye in 16 rabbits dilated with phenylephrine hydrochloride and cyclopentolate hydrochloride. The pupil diameters were measured at baseline, then the rabbits' anterior chambers were irrigated with an acetylcholine solution. The resultant pupillary diameters were measured at one and five minutes. At five minutes post-irrigation there was a statistically significant greater constriction in the control group than in the Ocufen group. This implies that Ocufen dampens the iris musculature's response to acetylcholine.

摘要

氟比洛芬（欧可芬），一种抗前列腺素药物，已被应用于白内障手术。它通过阻断炎症介质的形成来防止术中瞳孔缩小。已注意到欧可芬可减少手术期间使用乙酰胆碱所产生的可控性瞳孔缩小。本研究评估了乙酰胆碱接触欧可芬后的瞳孔反应。这是通过对16只使用盐酸去氧肾上腺素和盐酸环喷托酯散瞳的兔子的对照眼和研究眼进行的。在基线时测量瞳孔直径，然后用乙酰胆碱溶液冲洗兔子的前房。在1分钟和5分钟时测量所得的瞳孔直径。冲洗后5分钟，对照组的瞳孔收缩在统计学上显著大于欧可芬组。这意味着欧可芬会抑制虹膜肌肉组织对乙酰胆碱的反应。