Diabetes Trials Unit, The Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, UK.
Nat Rev Endocrinol. 2013 Feb;9(2):67-8. doi: 10.1038/nrendo.2012.243. Epub 2013 Jan 8.
Worldwide, >366 million people with type 2 diabetes mellitus remain at excess risk of cardiovascular disease and face a lifetime of treatment escalation for this progressive disorder. Studies in 2012 have re-affirmed the safety of early insulin treatment, metformin use in renal impairment, and shown β-cell function preservation over several years.
全球范围内，超过 3.66 亿 2 型糖尿病患者仍然面临心血管疾病的风险增加，并且这种进行性疾病需要终身治疗升级。2012 年的研究再次证实了早期胰岛素治疗的安全性、肾功能损害时使用二甲双胍的安全性，并显示出多年来对β细胞功能的保护作用。
