Sabo Jennifer K, Cate Holly S
Centre for Neuroscience Research, Department of Anatomy and Neuroscience, University of Melbourne, Melbourne Brain Centre, Kenneth Myer Building, 30 Royal Parade, Parkville, Vic 3010, Australia.
Int J Mol Sci. 2013 Jan 7;14(1):1031-49. doi: 10.3390/ijms14011031.
In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are promising strategies for treatment in demyelinating disorders. Endogenous precursor cells or exogenous transplanted cells are potential sources for remyelinating oligodendrocytes in the central nervous system (CNS). Several signalling pathways have been implicated in regulating the capacity of these cell populations for myelin repair. Here, we review neural precursor cells and oligodendrocyte progenitor cells as potential sources for remyelinating oligodendrocytes and evidence for the functional role of key signalling pathways in inhibiting regeneration from these precursor cell populations.
在诸如多发性硬化症（MS）等脱髓鞘疾病中，损伤靶点是髓鞘和少突胶质细胞，导致严重的神经功能障碍。旨在促进少突胶质细胞成熟和髓鞘再生的再生疗法是治疗脱髓鞘疾病的有前景的策略。内源性前体细胞或外源性移植细胞是中枢神经系统（CNS）中进行髓鞘再生的少突胶质细胞的潜在来源。几种信号通路已被证明与调节这些细胞群体进行髓鞘修复的能力有关。在这里，我们综述了神经前体细胞和少突胶质细胞祖细胞作为进行髓鞘再生的少突胶质细胞的潜在来源，以及关键信号通路在抑制这些前体细胞群体再生方面的功能作用的证据。
