Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Clin J Am Soc Nephrol. 2013 Jan;8(1):154-61. doi: 10.2215/CJN.05870612.
Lupus nephritis (LN) remains a major cause of ESRD and is associated with a >4-fold increase in mortality and significant morbidity in patients with lupus. The treatment of LN has evolved significantly over the past decade due to data from well conducted randomized controlled trials. We are currently in an era in which effective regimens exist in the form of induction and maintenance agents. Histopathologic classification of LN remains one of the main factors guiding therapy.
狼疮性肾炎 (LN) 仍然是导致终末期肾病的主要原因，与狼疮患者的死亡率增加超过 4 倍和显著发病率相关。由于精心设计的随机对照试验的数据，LN 的治疗在过去十年中发生了重大变化。我们目前正处于一个有效治疗方案以诱导和维持药物的形式存在的时代。LN 的组织病理学分类仍然是指导治疗的主要因素之一。
