Zhang Hui, Li Mengli, Mao Zhiyu, Yin Tongtong, Qi Jiaying, Wang Fangfang, Wang Li
School of Nursing, Suzhou Vocational Health College, Suzhou, Jiangsu, 215009, People's Republic of China.
School of Nursing, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China.
Int J Gen Med. 2024 Dec 19;17:6393-6405. doi: 10.2147/IJGM.S490060. eCollection 2024.
Blood flow restriction training (BFRT) can produce effects similar to high-intensity exercise at lower intensities, making it a potentially more suitable method for older adults with sarcopenia. This study aims to determine the efficacy of the intervention on improving physical fitness in older adults with sarcopenia when blood flow restriction (BFR) and aerobic exercise (AE) are combined (BFR-AE) and to explore the related metabolic and signaling mechanisms.
This is a three-arm, parallel, randomized controlled trial. A total of 171 participants, aged 60 to 90 years, with sarcopenia will be randomly assigned (1:1:1) into one of three groups: a control group, an AE group, and a BFR-AE group. The participants in the control group will maintain their usual diet and activity habits. Those in the AE and BFR-AE groups will undergo a 12-week program of AE and BFR-AE respectively. The primary outcomes will include two long-term indicators: the 6-minutes walking test and 30-s chair stand test. Secondary outcomes will include additional long-term measures (eg, appendicular skeletal muscle mass index, handgrip strength, five-time chair stand test, lower extremity knee extensor and flexor muscle strength, sleep quality, emotion status, serum metabonomic and signal proteins), as well as instantaneous indicators (eg, blood pressure, heart rate, saturation of pulse oxygen, rating of perceived exertion, pain score and blood lactate concentration), adherence to exercise, and adverse events. Outcomes will be assessed at one of or all the time points of baseline, 12 and 24 weeks.
It is expected that, after 12 weeks of intervention, both exercise groups will show improvements in cardiorespiratory and muscular fitness, with the BFR-AE group demonstrating greater benefits than the AE group alone.
血流限制训练（BFRT）在较低强度下可产生与高强度运动相似的效果，使其成为肌少症老年人潜在更合适的方法。本研究旨在确定血流限制（BFR）与有氧运动（AE）联合（BFR-AE）干预对改善肌少症老年人身体素质的疗效，并探索相关的代谢和信号机制。
这是一项三臂、平行、随机对照试验。总共171名年龄在60至90岁的肌少症参与者将被随机分配（1:1:1）到三个组之一：对照组、AE组和BFR-AE组。对照组的参与者将保持其通常的饮食和活动习惯。AE组和BFR-AE组的参与者将分别接受为期12周的AE和BFR-AE计划。主要结局将包括两个长期指标：6分钟步行试验和30秒坐立试验。次要结局将包括额外的长期测量指标（如四肢骨骼肌质量指数、握力、五次坐立试验、下肢膝关节伸肌和屈肌力量、睡眠质量、情绪状态、血清代谢组学和信号蛋白），以及即时指标（如血压、心率、脉搏血氧饱和度、自觉运动强度分级、疼痛评分和血乳酸浓度）、运动依从性和不良事件。结局将在基线、12周和24周中的一个或所有时间点进行评估。
预计在12周的干预后，两个运动组的心肺和肌肉功能都将有所改善，BFR-AE组显示出比单独的AE组更大的益处。
