Hadley M, Draper H H
Department of Nutritional Sciences, College of Biological Science, University of Guelph, Ontario, Canada.
Lipids. 1990 Feb;25(2):82-5. doi: 10.1007/BF02562209.
A 1:1 adduct of guanine with malondialdehyde (MDA) was isolated from rat and human urine. This compound was shown to be identical to a synthetic adduct prepared according to the procedure of Seto et al. (Bull. Chem. Soc. Jpn. 58, 3431-3435, 1985). The UV, NMR and other characteristics of the compound were consistent with the tricyclic pyrimidinopurine structure proposed by these investigators. Its endogenous origin is indicated by its presence in the urine of rats fed an MDA-free diet, and by the observation that its excretion increased following iron or carbon tetrachloride administration. It may serve as a marker for nucleic acid modification caused by lipid peroxidation in vivo.
从大鼠和人类尿液中分离出鸟嘌呤与丙二醛（MDA）的1:1加合物。该化合物被证明与根据濑户等人的方法制备的合成加合物相同（《日本化学会通报》58, 3431 - 3435, 1985）。该化合物的紫外光谱、核磁共振光谱及其他特征与这些研究者提出的三环嘧啶嘌呤结构一致。其内源性来源通过以下方面得以表明：在喂食无MDA饮食的大鼠尿液中存在该化合物，以及观察到在给予铁或四氯化碳后其排泄量增加。它可能作为体内脂质过氧化引起的核酸修饰的标志物。
