Ambrose Christopher S, Toback Seth L
MedImmune, LLC, Gaithersburg, MD 20878, USA.
Clin Pediatr (Phila). 2013 Mar;52(3):224-30. doi: 10.1177/0009922812470868. Epub 2013 Jan 8.
The Vaccines for Children (VFC) program distributes one half of all vaccines administered to US children. Compared with commercial vaccine distribution, VFC distribution is more complex. This prospective observational study compares the delivery and administration of VFC versus non-VFC influenza vaccine in US pediatricians' offices across 3 influenza seasons and its apparent impact on 2-dose compliance rates. Because of earlier shipping (mean = 29-42 days) of non-VFC vaccines, administration of VFC vaccines was delayed relative to non-VFC vaccines by approximately 1 month in 2007-2008 and 2008-2009 and 2 weeks in 2010-2011. Two-dose compliance rates for the VFC and non-VFC populations were 38.5% and 47.5% (P < .001) in 2007-2008, 45.9% and 55.1% (P < .001) in 2008-2009, and 50.0% and 52.9% (P < .001) in 2010-2011, respectively. Despite delays, earlier VFC shipment in 2010-2011 enabled greater equity in 2-dose compliance.
儿童疫苗（VFC）计划提供了全美儿童接种疫苗总量的一半。与商业疫苗分发相比，VFC分发更为复杂。这项前瞻性观察性研究比较了在美国儿科诊所中，三个流感季节里VFC流感疫苗与非VFC流感疫苗的配送及接种情况，以及其对两剂次接种合规率的明显影响。由于非VFC疫苗的发货时间更早（平均为29 - 42天），在2007 - 2008年和2008 - 2009年，VFC疫苗的接种相对于非VFC疫苗延迟了约1个月，在2010 - 2011年延迟了2周。2007 - 2008年，VFC和非VFC人群的两剂次接种合规率分别为38.5%和47.5%（P < 0.001），2008 - 2009年分别为45.9%和55.1%（P < 0.001），2010 - 2011年分别为50.0%和52.9%（P < 0.001）。尽管有延迟，但2010 - 2011年VFC疫苗更早的发货使得两剂次接种合规方面的公平性更高。
