Respiratory Department, Sir Charles Gairdner Hospital, Perth, Australia.
Thorax. 2013 Jun;68(6):594-6. doi: 10.1136/thoraxjnl-2012-203043. Epub 2013 Jan 7.
Few data exist on the pleurodesis outcome in patients with malignant pleural mesothelioma (MPM). A retrospective review of the Western Australian Mesothelioma Registry over 5 years revealed 390 evaluable patients. Only a subset of patients (42.3%) underwent pleurodesis, surgically (n=78) or by bedside instillation of sclerosants (n=87). Surgical pleurodesis showed no advantages over bedside pleurodesis in efficacy (32% vs 31% failures requiring further drainage, p=0.98), patient survival (p=0.52) or total time spent in hospital from procedure till death (p=0.36). No clinical, biochemical or radiographic parameters tested adequately predict pleurodesis outcome.
关于恶性胸膜间皮瘤（MPM）患者胸膜固定术的结果，相关数据较少。对西澳大利亚间皮瘤登记处超过 5 年的回顾性研究显示，390 例可评估患者。仅有一部分患者（42.3%）接受了胸膜固定术，包括手术（n=78）或床边硬化剂滴注（n=87）。手术胸膜固定术在疗效（需要进一步引流的失败率为 32%与 31%，p=0.98）、患者生存（p=0.52）或从手术到死亡在院总时间（p=0.36）方面，与床边胸膜固定术相比没有优势。没有经过充分测试的临床、生化或影像学参数能够充分预测胸膜固定术的结果。
