Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia 30329, USA.
J Am Geriatr Soc. 2013 Jan;61(1):67-73. doi: 10.1111/jgs.12067. Epub 2013 Jan 10.
To determine whether high blood pressure (BP) levels are associated with faster decline in specific cognitive domains.
Prospective longitudinal cohort.
Uniform Data Set of the National Institutes of Health, National Institute on Aging Alzheimer's Disease Centers.
One thousand three hundred eighty-five participants with a diagnosis of mild cognitive impairment (MCI) and measured BP values at baseline and two annual follow-up visits.
Neuropsychological test scores and Clinical Dementia Rating Sum of Boxes (CDR Sum) score.
Participants with MCI with two or three annual occasions of high BP values (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) had significantly faster decline on neuropsychological measures of visuomotor sequencing, set shifting, and naming than those who were normotensive on all three occasions. High systolic BP values were associated as well with faster decline on the CDR Sum score.
Hypertension is associated with faster cognitive decline in persons at risk for dementia.
确定高血压（BP）水平是否与特定认知领域的衰退速度加快有关。
前瞻性纵向队列研究。
美国国立卫生研究院、美国国立老化研究所阿尔茨海默病中心的统一数据集。
1385 名轻度认知障碍（MCI）患者，在基线和两次年度随访时测量血压值。
神经心理学测试分数和临床痴呆评定量表总和评分（CDR Sum）。
在有两到三次年度高血压值（收缩压≥140mmHg 或舒张压≥90mmHg）的 MCI 参与者中，与所有三次血压正常的参与者相比，在视动序列、转换思维和命名等神经心理学测试指标上的下降速度明显更快。收缩压升高也与 CDR Sum 评分的下降速度加快有关。
高血压与痴呆风险人群的认知衰退速度加快有关。
