浆细胞样树突状细胞中的 Toll 样受体 9 无法检测细小病毒。
Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses.
机构信息
Department of Immunobiology, Yale University, New Haven, CT, USA.
出版信息
J Virol. 2013 Mar;87(6):3605-8. doi: 10.1128/JVI.03155-12. Epub 2013 Jan 9.
Abstract
Toll-like receptor 9 (TLR9) recognizes genomes of double-stranded DNA (dsDNA) viruses in the endosome to stimulate plasmacytoid dendritic cells (pDCs). However, how and if viruses with single-stranded DNA (ssDNA) genomes are detected by pDCs remain unclear. Here we have shown that despite the ability of purified genomic DNA to stimulate TLR9 and despite the ability to enter TLR9 endosomes, ssDNA viruses of the Parvoviridae family failed to elicit an interferon (IFN) response in pDCs.
摘要
Toll 样受体 9（TLR9）在内涵体内识别双链 DNA（dsDNA）病毒的基因组，以刺激浆细胞样树突状细胞（pDC）。然而，单链 DNA（ssDNA）基因组的病毒是否以及如何被 pDC 检测到仍不清楚。在这里，我们已经表明，尽管纯化的基因组 DNA 能够刺激 TLR9，并且能够进入 TLR9 内涵体，但细小病毒科的 ssDNA 病毒未能在 pDC 中引发干扰素（IFN）反应。
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