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浆细胞样树突状细胞中的 Toll 样受体 9 无法检测细小病毒。

Toll-like receptor 9 in plasmacytoid dendritic cells fails to detect parvoviruses.

机构信息

Department of Immunobiology, Yale University, New Haven, CT, USA.

出版信息

J Virol. 2013 Mar;87(6):3605-8. doi: 10.1128/JVI.03155-12. Epub 2013 Jan 9.

DOI:10.1128/JVI.03155-12
PMID:23302877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3592163/
Abstract

Toll-like receptor 9 (TLR9) recognizes genomes of double-stranded DNA (dsDNA) viruses in the endosome to stimulate plasmacytoid dendritic cells (pDCs). However, how and if viruses with single-stranded DNA (ssDNA) genomes are detected by pDCs remain unclear. Here we have shown that despite the ability of purified genomic DNA to stimulate TLR9 and despite the ability to enter TLR9 endosomes, ssDNA viruses of the Parvoviridae family failed to elicit an interferon (IFN) response in pDCs.

摘要

Toll 样受体 9（TLR9）在内涵体内识别双链 DNA（dsDNA）病毒的基因组，以刺激浆细胞样树突状细胞（pDC）。然而，单链 DNA（ssDNA）基因组的病毒是否以及如何被 pDC 检测到仍不清楚。在这里，我们已经表明，尽管纯化的基因组 DNA 能够刺激 TLR9，并且能够进入 TLR9 内涵体，但细小病毒科的 ssDNA 病毒未能在 pDC 中引发干扰素（IFN）反应。

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本文引用的文献

1
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J Virol. 2012 Jan;86(1):69-80. doi: 10.1128/JVI.06119-11. Epub 2011 Oct 19.
2
Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase. Toll 样受体通过半胱天冬酶和天冬酰胺内肽酶的逐步加工来识别核酸。
J Exp Med. 2011 Apr 11;208(4):643-51. doi: 10.1084/jem.20100682. Epub 2011 Mar 14.
3
Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3.衔接蛋白 3 对 Toll 样受体 9 信号的分支作用。
Science. 2010 Sep 17;329(5998):1530-4. doi: 10.1126/science.1187029.
4
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice.TLR9-MyD88信号通路对小鼠腺相关病毒基因治疗载体的适应性免疫反应至关重要。
J Clin Invest. 2009 Aug;119(8):2388-98. doi: 10.1172/JCI37607. Epub 2009 Jul 1.
5
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9.Toll样受体9的激活需要在内溶酶体区室中进行蛋白水解切割。
Nat Immunol. 2008 Dec;9(12):1407-14. doi: 10.1038/ni.1669. Epub 2008 Oct 19.
6
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.Toll样受体9的胞外域被切割以产生功能性受体。
Nature. 2008 Dec 4;456(7222):658-62. doi: 10.1038/nature07405. Epub 2008 Sep 28.
7
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation.DNA糖骨架2'-脱氧核糖决定Toll样受体9的激活。
Immunity. 2008 Mar;28(3):315-23. doi: 10.1016/j.immuni.2008.01.013.
8
VP2 cleavage and the leucine ring at the base of the fivefold cylinder control pH-dependent externalization of both the VP1 N terminus and the genome of minute virus of mice.VP2切割以及五重圆柱体底部的亮氨酸环控制小鼠微小病毒VP1 N末端和基因组的pH依赖性外化。
J Virol. 2006 Jan;80(1):161-71. doi: 10.1128/JVI.80.1.161-171.2006.
9
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.Toll样受体9的细胞内定位可防止识别自身DNA，但有助于接触病毒DNA。
Nat Immunol. 2006 Jan;7(1):49-56. doi: 10.1038/ni1280. Epub 2005 Dec 11.
10
B1 lymphocytes and myeloid dendritic cells in lymphoid organs are preferential extratumoral sites of parvovirus minute virus of mice prototype strain expression.淋巴器官中的B1淋巴细胞和髓样树突状细胞是小鼠细小病毒原型株表达的肿瘤外优先位点。
J Virol. 2005 Mar;79(6):3517-24. doi: 10.1128/JVI.79.6.3517-3524.2005.