Ishii K, Tadokoro K, Nishimaki H, Nakazawa K, Matsubayashi T, Ishibashi A, Ishida H
Department of Radiology, School of Medicine, Kitasato University.
Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Jan 25;50(1):68-75.
Renoscintigraphy using 123I-orthoiodohipprate (123I-OIH) was conducted, and the dynamic imaging study results and the renograms were analyzed. The results using 123I-OIH were compared with those using 131I-OIH in 22 of 33 patients. Measurement of the effective renal blood flow (ERBF) was also performed using 123I-OIH by the single blood-sample method. 123I is a more suitable nuclide for gamma-camera scintigraphy than 131I in terms of physical characteristics, and a larger dose of 123I-OIH is possible than 131I-OIH because of its lesser radiation. These are the reasons why clearer dynamic images of the blood flow phase, functional phase and excretion phase can be obtained. These make possible diagnoses associated with the organic changes and functions. No essential differences could be found in the functional study results of renogram between the two drugs because on the nuclide of 131I is replaced by 123I, but a renogram with less statistical noise could be obtained using 123I-OIH than 131I-OIH. The radiation dose of 123I-OIH is less than that of 131I-OHI, and clearer dynamic images and functional indexes can be easily obtained in scintigraphy using 123I-OIH. It is concluded that 123I-OIH is a useful radiopharmaceutical for renal examination, and it should replace 131I-OIH.
采用123I-邻碘马尿酸（123I-OIH）进行了肾闪烁显像，并对动态成像研究结果和肾图进行了分析。在33例患者中的22例中，将使用123I-OIH的结果与使用131I-OIH的结果进行了比较。还采用单血样法使用123I-OIH对有效肾血流量（ERBF）进行了测量。就物理特性而言，123I比131I更适合用于γ相机闪烁显像，并且由于其辐射较小，123I-OIH的使用剂量可以比131I-OIH更大。这些就是能够获得更清晰的血流相、功能相和排泄相动态图像的原因。这些使得与器官变化和功能相关的诊断成为可能。两种药物在肾图功能研究结果方面未发现本质差异，因为只是将131I的核素替换为123I，但使用123I-OIH比131I-OIH能获得统计噪声更小的肾图。123I-OIH的辐射剂量低于131I-OHI，并且在使用123I-OIH的闪烁显像中能够轻松获得更清晰的动态图像和功能指标。结论是123I-OIH是一种用于肾脏检查的有用放射性药物，应取代131I-OIH。
