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3
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3.
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Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.
Nat Biotechnol. 2013 Jan;31(1):54-62. doi: 10.1038/nbt.2465. Epub 2012 Dec 16.
5
Molecular pathway for the localized formation of the sinoatrial node.
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Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells.
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8
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.
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Teed off: cardiac conduction system development requires T-box transcription factors.
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Pacing the Heart with Genes: Recent Progress in Biological Pacing.
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Heart Rhythm Harmony Becomes Discordant as We Age.
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2
Heartbeat music.
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3
Genetically Modified Porcine Mesenchymal Stem Cells by Lentiviral Tbx18 Create a Biological Pacemaker.
Stem Cells Int. 2019 Nov 7;2019:3621314. doi: 10.1155/2019/3621314. eCollection 2019.

本文引用的文献

1
Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.
Nat Biotechnol. 2013 Jan;31(1):54-62. doi: 10.1038/nbt.2465. Epub 2012 Dec 16.
2
Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2.
Circulation. 2012 Jul 31;126(5):528-36. doi: 10.1161/CIRCULATIONAHA.111.083584. Epub 2012 Jun 29.
3
T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.
Cardiovasc Res. 2012 Jun 1;94(3):439-49. doi: 10.1093/cvr/cvs120. Epub 2012 Mar 14.
4
The road to biological pacing.
Nat Rev Cardiol. 2011 Aug 16;8(11):656-66. doi: 10.1038/nrcardio.2011.120.
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Catecholamine-synthesizing cells in the embryonic mouse heart.
Ann N Y Acad Sci. 2008 Dec;1148:317-24. doi: 10.1196/annals.1410.008.
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CREB: the unindicted cancer co-conspirator.
Trends Cell Biol. 2005 Sep;15(9):457-9. doi: 10.1016/j.tcb.2005.07.007.
8
Expression and function of a biological pacemaker in canine heart.
Circulation. 2003 Mar 4;107(8):1106-9. doi: 10.1161/01.cir.0000059939.97249.2c.
9
Biological pacemaker created by gene transfer.
Nature. 2002 Sep 12;419(6903):132-3. doi: 10.1038/419132b.

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