Department of Surgery and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, USA.
Physiol Rev. 2013 Jan;93(1):189-268. doi: 10.1152/physrev.00015.2012.
Calcium balance is essential for a multitude of physiological processes, ranging from cell signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a major factor for maintaining systemic calcium homeostasis. Recent observations indicate that a reduction of gastric acidity may impair effective calcium uptake through the intestine. This article reviews the physiology of gastric acid secretion, intestinal calcium absorption, and their respective neuroendocrine regulation and explores the physiological basis of a potential link between these individual systems.
钙平衡对于多种生理过程至关重要，从细胞信号传递到骨骼健康维护。钙的充分肠道吸收是维持全身钙平衡的主要因素。最近的观察表明，胃酸减少可能会通过肠道损害有效钙吸收。本文综述了胃酸分泌、肠道钙吸收及其各自的神经内分泌调节的生理学，并探讨了这些个体系统之间潜在联系的生理学基础。
