Kitay Alice M, Geibel John P
Department of Surgery, Yale School of Medicine, New Haven, CT, USA.
Adv Exp Med Biol. 2017;1033:97-131. doi: 10.1007/978-3-319-66653-2_6.
The relation between gastrointestinal organs and bone metabolism has become clearer during the last decades. Of paramount importance is the tight and intertwined regulation of gastric acid secretion and bone metabolism in regard of diseases caused by dysfunction of any of these or intermediary organs or mediators. The importance of the functions of the endocrine modulators 1,25(OH) vitamin D (calcitriol), PTH, and calcitonin becomes clear when seeing misbalances and its impact on the skeleton. Another important player in the gut-bone signaling axis is calcium, which is operating through the calcium-sensing receptor (CaSR). The CaSR is located on diverse tissues of the human body, such as the parathyroid glands, stomach, intestine, and kidney. The strict regulation of calcium homeostasis is of high importance and any disturbances have immense consequences for the body. Mechanisms and therapeutic implications, as well as diseases caused by imbalances on the stomach-bone signaling axis, are highlighted in the following chapter.
在过去几十年间，胃肠器官与骨代谢之间的关系已变得更加清晰。在由这些器官或中间器官或介质功能障碍引起的疾病方面，胃酸分泌与骨代谢的紧密且相互交织的调节至关重要。当看到内分泌调节因子1,25(OH)维生素D（骨化三醇）、甲状旁腺激素（PTH）和降钙素的失衡及其对骨骼的影响时，它们功能的重要性就变得显而易见。肠-骨信号轴中的另一个重要参与者是钙，它通过钙敏感受体（CaSR）发挥作用。CaSR位于人体的多种组织上，如甲状旁腺、胃、肠道和肾脏。严格调节钙稳态非常重要，任何干扰都会给身体带来巨大后果。胃-骨信号轴失衡所导致的机制、治疗意义以及疾病将在以下章节中重点介绍。
