Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, No. 1 Yi-Da Road, Jiau-Shu Village, Yan-Chao District, Kaohsiung 82445, Taiwan.
Mediators Inflamm. 2012;2012:469852. doi: 10.1155/2012/469852. Epub 2012 Dec 13.
We demonstrated that visfatin expressed in monocytes and neutrophils and increased their reactivity in male acute ST-segment elevation myocardial infarction patients. Furthermore, visfatin was strongly appeared in lipid rich coronary rupture plaques and macrophages. These results suggest another explanation about leukocytes mediated visfatin that may play a pathogenesis role in coronary vulnerable plaques rupture.
我们证明了在单核细胞和中性粒细胞中表达的内脏脂肪素增加了男性急性 ST 段抬高型心肌梗死患者的反应性。此外，内脏脂肪素在富含脂质的冠状动脉破裂斑块和巨噬细胞中强烈出现。这些结果提示了白细胞介导内脏脂肪素的另一种解释，它可能在易损斑块破裂的发病机制中发挥作用。
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