血液透析的尿毒症患者获得性穿通性皮肤病的预测因素：一项病例对照研究。
Predictors of acquired perforating dermatosis in uremic patients on hemodialysis: a case-control study.
作者信息
Weng Cheng-Hao, Hu Ching-Chih, Ueng Shir-Hwa, Yu Chun-Chen, Hui Chung-Yee, Lin Ja-Liang, Yang Chih-Wei, Hung Cheng-Chieh, Hsu Ching-Wei, Yen Tzung-Hai
机构信息
Department of Nephrology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kwei-Shan, Taoyuan 333, Taiwan.
出版信息
ScientificWorldJournal. 2012;2012:158075. doi: 10.1100/2012/158075. Epub 2012 Dec 11.
OBJECTIVES
The purpose of this study was to identify the predictors of acquired perforating dermatosis (APD) in patients on maintenance hemodialysis (HD).
METHODS
A case-control study was performed at our outpatient HD center between January 1, 2000 and March 31, 2011. Patients on HD with APD were matched (1 : 2) for gender and age with controls on HD. Conditional logistic regression was used to identify factors associated with APD.
RESULTS
A total of 19 patients with APD and 38 age and gender matched patients were enrolled in the study. Univariate logistic regression showed that APD was significantly associated with diabetes mellitus (DM), reduced levels of intact parathyroid hormone (iPTH) and albumin (Alb), reduced dialysis adequacy (Kt/V) and urea reduction rate (URR), and elevated levels of high-sensitivity C-reactive protein (hsCRP). Multivariate logistic regression identified reduced iPTH (hazard ratio (HR): 0.983; P = 0.026) and Alb (HR: 0.099; P = 0.047) and elevated hsCRP (HR: 1.210, P = 0.024) as risk factors for APD.
CONCLUSIONS
iPTH, hsCRP, and Alb are predictors for APD in HD patients.
目的
本研究旨在确定维持性血液透析（HD）患者获得性穿通性皮肤病（APD）的预测因素。
方法
2000年1月1日至2011年3月31日在我们的门诊血液透析中心进行了一项病例对照研究。患有APD的HD患者在性别和年龄上与HD对照患者进行匹配（1∶2）。采用条件逻辑回归来确定与APD相关的因素。
结果
共有19例APD患者和38例年龄及性别匹配的患者纳入本研究。单因素逻辑回归显示，APD与糖尿病（DM）、完整甲状旁腺激素（iPTH）和白蛋白（Alb）水平降低、透析充分性（Kt/V）和尿素清除率（URR）降低以及高敏C反应蛋白（hsCRP）水平升高显著相关。多因素逻辑回归确定iPTH降低（风险比（HR）：0.983；P = 0.026）、Alb降低（HR：0.099；P = 0.047）和hsCRP升高（HR：1.210，P = 0.024）为APD的危险因素。
结论
iPTH、hsCRP和Alb是HD患者APD的预测因素。
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