黄曲霉毒素对美利奴公羊肝脏的影响及酯化葡甘露聚糖的保护效果。
Effects of aflatoxin on liver and protective effectiveness of esterified glucomannan in Merino rams.
作者信息
Colakoglu Fatma, Donmez Hasan Hüseyin
机构信息
Department of Histology and Embryology, Faculty of Veterinary Medicine, Selçuk University, 42075 Konya, Turkey.
出版信息
ScientificWorldJournal. 2012;2012:462925. doi: 10.1100/2012/462925. Epub 2012 Dec 13.
The effects of total aflatoxin (AF) given orally on liver in Merino rams were studied. In addition, this study was conducted in order to evaluate the efficacy of an esterified glucomannan (EG) for protection against aflatoxicosis. One-year-old 32 Merino rams were divided into four equal groups. The control group (C) was fed with the commercial feed. The AF group was fed with commercial feed plus 250 μg/day of total AF. The EG group was fed with commercial feed plus 2 g/day of EG. The AF + EG group was fed with commercial feed plus 250 μg/day of total AF and 2 g/day of EG. After feeding period, tissue samples were taken from the liver in order to perform histological analyses. Vacuolar degeneration with small and large droplets and hydropic degeneration in hepatocytes were observed in the AF group. The ceroid pigmentation was observed in macrophages in groups or one by one. It was observed that the fat rate in hepatocytes was 2.6% in the C group, 35.5% in the AF group, 2.9% in the EG group, and 9.6% in the AF + EG group. In conclusion, the adverse effects caused by aflatoxicosis on the liver could be ameliorated by adding EG to the ration.
研究了口服总黄曲霉毒素（AF）对美利奴公羊肝脏的影响。此外，进行本研究以评估酯化葡甘露聚糖（EG）预防黄曲霉毒素中毒的效果。将32只一岁的美利奴公羊分成四组，每组数量相等。对照组（C）饲喂商业饲料。AF组饲喂商业饲料加250μg/天的总AF。EG组饲喂商业饲料加2g/天的EG。AF + EG组饲喂商业饲料加250μg/天的总AF和2g/天的EG。饲喂期结束后，采集肝脏组织样本进行组织学分析。在AF组中观察到肝细胞出现大小液滴的空泡变性和水样变性。在各组中或逐个巨噬细胞中观察到类脂色素沉着。观察到C组肝细胞脂肪率为2.6%，AF组为35.5%，EG组为2.9%，AF + EG组为9.6%。总之，在日粮中添加EG可改善黄曲霉毒素中毒对肝脏造成的不良影响。
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