Poudrier Johanne, Thibodeau Valérie, Roger Michel
Laboratoire d'Immunogénétique, Centre de Recherche, Centre Hospitalier de l'Université de Montréal (CRCHUM) et Département de Microbiologie et Immunologie, Université de Montréal, Montreal, QC, Canada H2L 4M1.
Clin Dev Immunol. 2012;2012:875821. doi: 10.1155/2012/875821. Epub 2012 Dec 11.
Understanding how the mucosal immune system in the human female reproductive tract might prevent or facilitate HIV infection has important implications for the design of effective interventions. We and others have established cohorts of highly-exposed, HIV-seronegative individuals, such as HIV-uninfected commercial sex workers, who have remained HIV-negative after more than 5 years of active prostitution. Observations obtained in studies of such individuals, who represent a model of natural immunity to HIV, indicate that HIV resistance may be associated with the host's capacity to preserve systemic integrity by constraining immune activity and controlling inflammatory conditions at the mucosal point of entry. This likely necessitates the orchestration of balanced, first-line and adaptive immune responses.
了解人类女性生殖道的黏膜免疫系统如何预防或促进HIV感染，对于设计有效的干预措施具有重要意义。我们和其他人建立了高暴露、HIV血清阴性个体的队列，例如未感染HIV的商业性工作者，她们在从事超过5年的性交易活动后仍保持HIV阴性。对这些个体的研究观察结果表明，HIV抗性可能与宿主通过限制免疫活动和控制黏膜入口处的炎症状况来维持全身完整性的能力有关。这可能需要协调平衡的一线免疫反应和适应性免疫反应。 此类个体代表了对HIV自然免疫的模型。
