Kerkerian Genevieve, Alimohammadi Arshia, Raycraft Tyler, Conway Brian
Vancouver Infectious Diseases Center.
Department of Medicine, University of British Columbia, Vancouver, Canada.
Infect Dis Rep. 2017 Oct 2;9(3):7142. doi: 10.4081/idr.2017.7142.
Hepatitis C Virus (HCV) and human immunodeficiency virus (HIV) are global pandemics that affect 170 million and 35 million individuals, respectively. Up to 45% of individuals infected with HCV clear their infections spontaneously - correlating to factors like aboriginal descent and some host specific immune factors. HIV, however, establishes true latency in infected cells and cannot be cured. In the setting of longterm non-progressors (LTNPs) of HIV, a state of immune preservation and low circulating viral load is established. Regarding HIV/HCV co-infection, little is known about the relationship between spontaneous clearance of HCV infection and long-term control of HIV infection without medical intervention. We describe a case of a HIV-infected female defined as a LTNP in whom spontaneous clearance of HCV was documented on multiple occasions. Similar cases should be documented and identified in an effort to develop novel hypotheses about the natural control of these infections and inform research on immune-based interventions to control them.
丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）是全球性大流行病，分别影响着1.7亿人和3500万人。高达45%的丙型肝炎病毒感染者会自发清除感染，这与原住民血统和一些宿主特异性免疫因素等有关。然而，HIV会在受感染细胞中建立真正的潜伏期，无法治愈。在HIV长期不进展者（LTNP）的情况下，会建立一种免疫保存和低循环病毒载量的状态。关于HIV/HCV合并感染，在没有医学干预的情况下，丙型肝炎病毒感染的自发清除与HIV感染的长期控制之间的关系知之甚少。我们描述了一例被定义为LTNP的HIV感染女性病例，该病例多次记录到丙型肝炎病毒的自发清除。应记录和识别类似病例，以便对这些感染的自然控制提出新的假设，并为基于免疫的干预措施的研究提供信息，以控制这些感染。
