Putadechakum Supanee, Klangjareonchai Theerawut, Soponsaritsuk Arpussanee, Roongpisuthipong Chulaporn
Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
ISRN Gastroenterol. 2012;2012:690402. doi: 10.5402/2012/690402. Epub 2012 Dec 4.
Background. Protein supplementation has been shown to be effective for the treatment of malnourished patients with liver cirrhosis. The parameters used to assess nutritional improvement in cirrhotic patients for such treatment are important. Objective. To evaluate the parameters for assessment of nutritional status in patients with liver cirrhosis after protein supplementation. Material and Method. A cross-sectional, prospective clinical trial with 22 cirrhotic patients was performed. Data from anthropometry, bioelectrical impedance, subjective global assessment (SGA), and visceral protein were gathered and analyzed to assess nutritional improvement after protein supplementation. Results. Twenty-two cirrhotic patients (mean age 52.9 ± 12.8 years; 54.5% male; 63.6% alcoholic cirrhosis; 63.6% Child-Pugh C) were recruited. After protein supplementation, a significant improvement was demonstrated in the SGA class A from 10 patients (45.5%) to 16 (72.7%) and 18 (81.8%) at the 4th and 8th weeks, respectively. Body weight, body mass index, and lean muscle mass were significantly increased from baseline at the 8th week. No significant change in other nutritional parameters was observed. Conclusions. The SGA and lean muscle mass were significant parameters in order to assess nutritional status in cirrhotic patients after protein supplementation.
背景。蛋白质补充已被证明对治疗肝硬化营养不良患者有效。用于评估此类治疗中肝硬化患者营养改善情况的参数很重要。目的。评估蛋白质补充后肝硬化患者营养状况的评估参数。材料与方法。对22例肝硬化患者进行了一项横断面、前瞻性临床试验。收集并分析了人体测量学、生物电阻抗、主观全面评定法（SGA）和内脏蛋白的数据，以评估蛋白质补充后的营养改善情况。结果。招募了22例肝硬化患者（平均年龄52.9±12.8岁；男性占54.5%；酒精性肝硬化占63.6%；Child-Pugh C级占63.6%）。蛋白质补充后，SGA A级患者在第4周时从10例（45.5%）显著改善至16例（72.7%），在第8周时改善至18例（81.8%）。第8周时体重、体重指数和瘦肌肉量较基线显著增加。未观察到其他营养参数有显著变化。结论。SGA和瘦肌肉量是评估蛋白质补充后肝硬化患者营养状况的重要参数。
