Girardet J-P, Rivero M, Orbegozo J, David T, Boulanger S, Moisson de Vaux A, Johnston S, Marin V
Gastroentérologie et nutrition pédiatriques, université Pierre-et-Marie-Curie-Paris 6, hôpital Armand-Trousseau, AP-HP, 26, avenue Arnold-Netter, 75012 Paris, France.
Arch Pediatr. 2013 Mar;20(3):323-8. doi: 10.1016/j.arcped.2012.12.002. Epub 2013 Jan 8.
The objective of this study was to assess the efficacy in terms of growth and tolerance of an infant formula based on hydrolyzed rice proteins.
Healthy infants, born at term, less than 1 month old, and exclusively fed an infant formula based on hydrolyzed rice proteins until their diet was diversified, were included in this open-label, multicenter study. The main outcome measure was daily weight gain during the study period. The infant's weight, height, body mass index (BMI), and the data concerning tolerance (digestive disorders, allergy manifestations) were collected at inclusion in the study, at 2 and 4 months, and before diversifying the infant's diet between 4 and 6 months. The growth parameters were compared to the WHO standards by calculating the Z-score.
Seventy-eight infants were included. The mean daily weight gain over 5 months was 23.2 ± 4.3 g/day, identical to the WHO standards (22.2 ± 1.8 g/day, P = 0.09). During the study period, the Z-scores for weight, height, and BMI varied between +1.1 and -0.5 SD according to the WHO standards. Formula acceptance and tolerance were both good.
The infant formula studied, based on hydrolyzed rice proteins, was well tolerated and led to normal growth over the first few months of life, comparable to the WHO standards.
本研究的目的是评估一种基于水解大米蛋白的婴儿配方奶粉在生长和耐受性方面的功效。
本开放标签、多中心研究纳入了足月出生、年龄小于1个月、仅喂养基于水解大米蛋白的婴儿配方奶粉直至饮食多样化的健康婴儿。主要结局指标是研究期间的每日体重增加量。在研究纳入时、2个月和4个月时以及在4至6个月婴儿饮食多样化之前，收集婴儿的体重、身高、体重指数（BMI）以及有关耐受性（消化紊乱、过敏表现）的数据。通过计算Z评分将生长参数与世界卫生组织标准进行比较。
纳入了78名婴儿。5个月期间的平均每日体重增加量为23.2±4.3克/天，与世界卫生组织标准（22.2±1.8克/天，P = 0.09）相同。在研究期间，根据世界卫生组织标准，体重、身高和BMI的Z评分在+1.1至 -0.5标准差之间变化。配方奶粉的接受度和耐受性均良好。
所研究的基于水解大米蛋白的婴儿配方奶粉耐受性良好，在生命的最初几个月导致正常生长，与世界卫生组织标准相当。
