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气道平滑肌在哮喘病理生理学和治疗中的作用。

Airway smooth muscle in the pathophysiology and treatment of asthma.

机构信息

Department of Medicine, University of Chicago, Chicago, IL, USA.

出版信息

J Appl Physiol (1985). 2013 Apr;114(7):834-43. doi: 10.1152/japplphysiol.00950.2012. Epub 2013 Jan 10.

DOI:10.1152/japplphysiol.00950.2012
PMID:23305987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3633438/
Abstract

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is responsible for acute bronchoconstriction, which is potentiated by constrictor hyperresponsiveness, impaired relaxation and length adaptation. ASM also contributes to airway remodeling and inflammation in asthma. In light of this, ASM is an important target in the treatment of asthma.

摘要

气道平滑肌（ASM）在哮喘的病理生理学中起着重要作用。它负责急性支气管收缩，而这种收缩会被收缩反应性增强、松弛受损和长度适应不良所加剧。ASM 也会导致哮喘中的气道重塑和炎症。鉴于此，ASM 是哮喘治疗的一个重要靶点。

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本文引用的文献

[1]
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J Appl Physiol (1985). 2013-4

[2]
A pilot study of the feasibility of confocal endomicroscopy for examination of the human airway.

J Bronchology Interv Pulmonol. 2010-4

[3]
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Lancet. 2012-8-18

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Eur Respir J. 2012-7-26

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Am J Respir Crit Care Med. 2012-6-7

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Airway smooth muscle hypertrophy and hyperplasia in asthma.

Am J Respir Crit Care Med. 2012-3-8

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A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation.

FASEB J. 2012-1-25

[9]
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.

J Clin Invest. 2012-1-9

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Muscarinic receptor antagonists: effects on pulmonary function.

Handb Exp Pharmacol. 2012

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