Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
Blood Purif. 2012;34(3-4):344-8. doi: 10.1159/000345518. Epub 2013 Jan 9.
BACKGROUND/AIM: We treated a patient with critical manganese intoxication with vigorous extracorporeal elimination. In this article, we describe the clinical characteristics and treatment modalities of the patient.
A 65-year-old man was brought to the emergency room (ER) 5.5 h after ingesting prochloraz-manganese complex. He experienced circulatory collapse and went into a coma without self-breathing on arrival at the ER. Mechanical ventilation was initiated and hemoperfusion, hemodialysis and continuous venovenous hemodiafiltration were performed with the help of norepinephrine. MEASUREMENT AND RESULT: The manganese levels on the first, second and fourth hospital days were 34.1, 23.6 and 12.5 µg/l, respectively. He recuperated from the shock state within 7 hospital days. After 4 critical weeks, the patient regained full consciousness.
Rigorous extracorporeal elimination by hemoperfusion, hemodialysis and continuous venovenous hemodiafiltration was an effective treatment modality for patients with acute manganese intoxication.
背景/目的：我们采用体外强化清除的方法治疗了一位重症锰中毒患者。本文描述了该患者的临床特点和治疗方法。
一位 65 岁男性在摄入百菌清-锰复合物后 5.5 小时被送入急诊室。他到达急诊室时已发生循环衰竭并昏迷，无自主呼吸，随即给予机械通气，并给予去甲肾上腺素辅助行血液灌流、血液透析和连续性静脉-静脉血液透析滤过。
入院第 1、2、4 天的锰浓度分别为 34.1、23.6 和 12.5µg/L。他在 7 天内从休克状态中恢复。经过 4 周的危险期后，患者恢复了完全意识。
血液灌流、血液透析和连续性静脉-静脉血液透析滤过等强化体外清除方法是治疗急性锰中毒患者的有效治疗手段。
