Herrero Hernandez Elena, Discalzi Gianluigi, Dassi Patrizia, Jarre Laura, Pira Enrico
Department of Traumatology, Orthopaedics and Occupational Health, Neurotoxicology Unit, CTO Hospital, University of Turin, Turin, Italy.
Neurotoxicology. 2003 Aug;24(4-5):633-9. doi: 10.1016/S0161-813X(03)00026-3.
Excess manganese (Mn) can cause several neurotoxic effects, however only a few studies have reported epileptic syndromes related to manganese intoxication. We describe an epileptic syndrome due to manganese intoxication in a 3 year old male child. His blood manganese was elevated, but no other abnormal values or toxic substances were found in blood or urine. The electroencephalogram (EEG) showed a picture of progressive encephalopathy, while brain magnetic resonance was normal. The patient's conditions rapidly worsened to epileptic status despite the use of antiepileptic drugs. Chelating treatment with CaNa(2)EDTA was initiated to remove excess manganese and promptly succeeded in reverting epileptic symptoms. Concurrently, manganese blood levels and electroencephalogram progressively normalized. Thereafter it has been possible to discontinue antiepileptic treatment, and the patient remains in excellent conditions without any treatment.
过量的锰（Mn）会导致多种神经毒性作用，然而仅有少数研究报道了与锰中毒相关的癫痫综合征。我们描述了一名3岁男童因锰中毒引发的癫痫综合征。他的血锰水平升高，但血液和尿液中未发现其他异常值或有毒物质。脑电图（EEG）显示为进行性脑病的表现，而脑部磁共振成像正常。尽管使用了抗癫痫药物，患者的病情仍迅速恶化为癫痫持续状态。开始使用依地酸钙钠（CaNa₂EDTA）进行螯合治疗以清除过量的锰，并迅速成功地使癫痫症状得到缓解。同时，血锰水平和脑电图逐渐恢复正常。此后，得以停用抗癫痫治疗，且患者在未接受任何治疗的情况下仍状况良好。
