Benemanskiĭ V V, Katul'skiĭ Iu N, Levina V Ia
Vopr Onkol. 1990;36(3):327-31.
In chronic experiments, albino noninbred rats were fed 20.0, 2.0 or 0.2 mg/l nitrosodimethylamine and 1000 or 100 mg/l ascorbic acid (average daily dose 100 or 10 mg/kg body weight). The study established the modifying effect of ascorbic acid on nitrosodimethylamine -- induced carcinogenesis. A decrease in tumor incidence was observed, particularly, at high level of the carcinogen. High dose ascorbic acid did not affect tumor incidence in intact animals; however, time to detection of the first tumor and mean duration of tumor development proved longer.
在慢性实验中，给非近亲繁殖的白化大鼠喂食20.0、2.0或0.2毫克/升的亚硝基二甲胺以及1000或100毫克/升的抗坏血酸（平均日剂量为100或10毫克/千克体重）。该研究确定了抗坏血酸对亚硝基二甲胺诱导的致癌作用的调节效应。观察到肿瘤发生率有所降低，尤其是在致癌物含量高的情况下。高剂量的抗坏血酸对未受影响的动物的肿瘤发生率没有影响；然而，首次发现肿瘤的时间以及肿瘤发展的平均持续时间都更长。
