Benemanskiĭ V V
Eksp Onkol. 1986;8(4):20-2.
It is proved in experiments with the interrupting and twenty-four hour inhalations and peroral use of nitrosodimethylamine on the Wistar and white rats, that blastomogenic effect is submitted to the dose-effect dependence. On the whole the tumour incidence is determined by a total dose of carcinogen but its size may vary to a considerable extent depending on the regime of nitrosodimethylamine delivery. The daily and single doses of carcinogen are of great importance. Relatively high daily doses introduced within a short period of time cause a greater effect than low doses introduced within a larger period of time. The greater blastomogenic effect is caused by a longer peroral introduction of the same daily dose.
在对Wistar大鼠和白色大鼠进行的亚硝基二甲胺间断吸入、24小时吸入及经口使用的实验中证明，致瘤作用符合剂量效应依赖性。总体而言，肿瘤发生率由致癌物的总剂量决定，但其大小可能会因亚硝基二甲胺给药方式的不同而在相当大的范围内变化。致癌物的每日剂量和单次剂量非常重要。在短时间内引入相对较高的每日剂量比在较长时间内引入低剂量产生的效果更大。相同每日剂量经口给药时间越长，致瘤作用越大。
