Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Hoegi-dong 1, Dongdaemoon-gu, Seoul, 130-702, South Korea.
Dig Dis Sci. 2013 May;58(5):1282-6. doi: 10.1007/s10620-012-2520-x. Epub 2013 Jan 10.
BACKGROUND/AIM: As the prevalence of reflux esophagitis increases, so does the use of gastric acid suppressants. This study aimed to document the prevalence of Candida esophagitis (CE) at a single Korean university hospital over the last 5 years and to evaluate its risk factors.
To investigate the prevalence of CE, we conducted a retrospective analysis of 55,314 individuals who underwent a screening esophagogastroduodenoscopy as part of a health check-up between January 2006 and December 2010 at Kyung Hee University Hospital in Seoul, Korea. A total of 250 patients who were treated for CE between January 2008 and August 2011 and 500 age- and sex-matched non-CE patients were enrolled in this study. The rates of recent gastric acid suppression therapy and other well-known risk factors in the two groups were compared.
The prevalence of CE was 0.35 % and increased each year (linear-by-linear association, P = 0.001). Univariate analysis showed that gastric acid suppression therapy, malignancy, DM and steroid therapy were related to CE. Multivariate analysis also showed that gastric acid suppression therapy (OR 5.11, 95 % CI 2.92-8.93 and P < 0.001), malignancy (OR 18.68, 95 % CI 6.37-54.75 and P < 0.001), DM (OR 2.67, 95 % CI 1.70-4.21 and P < 0.001) and steroids therapy (OR 6.74, 95 % CI 1.37-33.05 and P = 0.019) were related to CE.
The prevalence of CE in Korea is increasing. Also, our results indicate that acid suppression therapy is a meaningful risk factor for CE.
背景/目的：随着反流性食管炎的患病率增加，胃酸抑制剂的使用也越来越多。本研究旨在记录过去 5 年在韩国一家大学医院中念珠菌性食管炎（CE）的患病率，并评估其危险因素。
为了调查 CE 的患病率，我们对 2006 年 1 月至 2010 年 12 月期间在首尔庆熙大学医院进行健康检查的 55314 名接受筛查性食管胃十二指肠镜检查的个体进行了回顾性分析。2008 年 1 月至 2011 年 8 月期间接受 CE 治疗的 250 例患者和 500 例年龄和性别匹配的非 CE 患者被纳入本研究。比较两组中近期胃酸抑制治疗和其他已知危险因素的发生率。
CE 的患病率为 0.35%，且逐年增加（线性趋势检验，P=0.001）。单因素分析显示，胃酸抑制治疗、恶性肿瘤、糖尿病和类固醇治疗与 CE 相关。多因素分析还显示，胃酸抑制治疗（OR 5.11，95%CI 2.92-8.93，P<0.001）、恶性肿瘤（OR 18.68，95%CI 6.37-54.75，P<0.001）、糖尿病（OR 2.67，95%CI 1.70-4.21，P<0.001）和类固醇治疗（OR 6.74，95%CI 1.37-33.05，P=0.019）与 CE 相关。
韩国 CE 的患病率正在增加。此外，我们的结果表明，酸抑制治疗是 CE 的一个有意义的危险因素。
