Tres Cantos Medicines Development Campus (TCMDC), GlaxoSmithKline (GSK), Severo Ochoa 2, Tres Cantos, Madrid, Spain.
ChemMedChem. 2013 Feb;8(2):313-21. doi: 10.1002/cmdc.201200428. Epub 2013 Jan 10.
With the aim of fuelling open-source, translational, early-stage drug discovery activities, the results of the recently completed antimycobacterial phenotypic screening campaign against Mycobacterium bovis BCG with hit confirmation in M. tuberculosis H37Rv were made publicly accessible. A set of 177 potent non-cytotoxic H37Rv hits was identified and will be made available to maximize the potential impact of the compounds toward a chemical genetics/proteomics exercise, while at the same time providing a plethora of potential starting points for new synthetic lead-generation activities. Two additional drug-discovery-relevant datasets are included: a) a drug-like property analysis reflecting the latest lead-like guidelines and b) an early lead-generation package of the most promising hits within the clusters identified.
为了推动开源、转化、早期药物发现活动，最近完成的针对牛分枝杆菌卡介苗的抗分枝杆菌表型筛选活动的结果已经公开，其中包括在结核分枝杆菌 H37Rv 中得到确认的阳性结果。已经确定了一组 177 种有效的非细胞毒性 H37Rv 阳性化合物，这些化合物将被提供出来，以最大限度地发挥化合物在化学遗传学/蛋白质组学研究中的潜力，同时为新的合成先导化合物生成活动提供大量潜在的起点。此外，还包括另外两个与药物发现相关的数据集：a）反映最新类先导化合物指南的药物特性分析，以及 b）在鉴定的聚类中最有前途的阳性化合物的早期先导化合物生成包。
