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Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH.

作者信息

Span Ingrid, Wang Ke, Wang Weixue, Jauch Johann, Eisenreich Wolfgang, Bacher Adelbert, Oldfield Eric, Groll Michael

机构信息

Center for Integrated Protein Science Munich, Chemie Department, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.

出版信息

Angew Chem Int Ed Engl. 2013 Feb 11;52(7):2118-21. doi: 10.1002/anie.201208469. Epub 2013 Jan 10.

DOI:10.1002/anie.201208469
PMID:23307751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3734547/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/157f65fa3083/nihms-500305-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/2b820bfb1cc7/nihms-500305-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/5da3edb7ebd0/nihms-500305-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/db668ca0c92c/nihms-500305-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/c4f5e65b9fd4/nihms-500305-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/a7e9f45d2268/nihms-500305-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/5c7b974ffe60/nihms-500305-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/577f38aa4ae1/nihms-500305-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/157f65fa3083/nihms-500305-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/2b820bfb1cc7/nihms-500305-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/5da3edb7ebd0/nihms-500305-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/db668ca0c92c/nihms-500305-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/c4f5e65b9fd4/nihms-500305-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/a7e9f45d2268/nihms-500305-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/5c7b974ffe60/nihms-500305-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/577f38aa4ae1/nihms-500305-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af2/3734547/157f65fa3083/nihms-500305-f0004.jpg

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本文引用的文献

1
Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.发现铁硫蛋白 IspH 的乙炔水化酶活性。
Nat Commun. 2012;3:1042. doi: 10.1038/ncomms2052.
2
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.自由基是否参与 IspH 催化作用？EPR 和晶体学研究。
J Am Chem Soc. 2012 Jul 11;134(27):11225-34. doi: 10.1021/ja303445z. Epub 2012 Jun 28.
3
A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.
配体与IspH结合的光谱学和计算研究：非二磷酸抑制剂的发现
Chembiochem. 2017 May 18;18(10):914-920. doi: 10.1002/cbic.201700052. Epub 2017 Apr 7.
4
New Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in Plasmodium.疟原虫中类异戊二烯生物合成过程的新见解及药物设计的未来前景
Front Microbiol. 2016 Sep 13;7:1421. doi: 10.3389/fmicb.2016.01421. eCollection 2016.
5
Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of the E. coli LytB/IspH Protein.致病细菌中的类异戊二烯生物合成：核磁共振振动光谱揭示大肠杆菌LytB/IspH蛋白中异常的[4Fe-4S]簇
Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12584-7. doi: 10.1002/anie.201502494. Epub 2015 Jun 26.
6
Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron-Sulfur Enzyme in Pathogenic Bacteria.致病性细菌中一种铁硫酶IspH反应途径的破缺对称密度泛函理论计算
Inorg Chem. 2015 Jul 6;54(13):6439-61. doi: 10.1021/acs.inorgchem.5b00751. Epub 2015 Jun 22.
7
Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation.对4Fe-4S蛋白IspG和IspH的抑制作用：一项电子顺磁共振、电子核双共振和高分辨超精细结构谱研究
Chem Sci. 2014 Apr 1;5(4):1642-1649. doi: 10.1039/C3SC53301H.
8
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Biochemistry. 2012 Jun 19;51(24):4835-49. doi: 10.1021/bi3001215. Epub 2012 Jun 7.
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The stereochemical course and mechanism of the IspH reaction.IspH反应的立体化学过程和机制。
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J Org Chem. 2012 Apr 20;77(8):3689-99. doi: 10.1021/jo300044q. Epub 2012 Mar 21.
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Chembiochem. 2012 Mar 19;13(5):674-83. doi: 10.1002/cbic.201100733. Epub 2012 Feb 20.
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Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis.突变 IspH 蛋白的晶体结构揭示了催化过程中底物羟甲基基团的旋转。
J Mol Biol. 2012 Feb 10;416(1):1-9. doi: 10.1016/j.jmb.2011.11.033. Epub 2011 Nov 23.
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Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.异戊二烯单元的生物合成：LytB/IspH酶的[4Fe-4S]簇与底物和抑制剂结合的穆斯堡尔光谱
Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11976-9. doi: 10.1002/anie.201104562. Epub 2011 Oct 19.
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Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues.使用氟取代的底物类似物研究异戊烯焦磷酸合酶（IPP 合酶），一种甲基赤藓醇磷酸途径中的关键酶。
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Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms.Fe(4)S(4)- 簇蛋白 IspH（LytB）的抑制作用：电子顺磁共振、金属环和机制。
J Am Chem Soc. 2010 May 19;132(19):6719-27. doi: 10.1021/ja909664j.