Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH.
作者信息
Span Ingrid, Wang Ke, Wang Weixue, Jauch Johann, Eisenreich Wolfgang, Bacher Adelbert, Oldfield Eric, Groll Michael
机构信息
Center for Integrated Protein Science Munich, Chemie Department, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
出版信息
Angew Chem Int Ed Engl. 2013 Feb 11;52(7):2118-21. doi: 10.1002/anie.201208469. Epub 2013 Jan 10.
Abstract
摘要
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本文引用的文献
1
Discovery of acetylene hydratase activity of the iron-sulphur protein IspH.发现铁硫蛋白 IspH 的乙炔水化酶活性。
Nat Commun. 2012;3:1042. doi: 10.1038/ncomms2052.
2
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.自由基是否参与 IspH 催化作用？EPR 和晶体学研究。
J Am Chem Soc. 2012 Jul 11;134(27):11225-34. doi: 10.1021/ja303445z. Epub 2012 Jun 28.
3
A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.深入研究野生型和突变型（E）-4-羟基-3-甲基-2-丁烯基二磷酸还原酶中可能的反应中间体的光谱性质。
Biochemistry. 2012 Jun 19;51(24):4835-49. doi: 10.1021/bi3001215. Epub 2012 Jun 7.
4
The stereochemical course and mechanism of the IspH reaction.IspH反应的立体化学过程和机制。
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4053-7. doi: 10.1002/anie.201201110. Epub 2012 Mar 12.
5
Organofluorine chemistry: synthesis and conformation of vicinal fluoromethylene motifs.有机氟化学：顺式氟亚甲基结构的合成与构象。
J Org Chem. 2012 Apr 20;77(8):3689-99. doi: 10.1021/jo300044q. Epub 2012 Mar 21.
6
Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro.灵活通用的功能化磷酸异戊烯基化合物合成方法，用于体内和体外的prenylation 研究。
Chembiochem. 2012 Mar 19;13(5):674-83. doi: 10.1002/cbic.201100733. Epub 2012 Feb 20.
7
Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis.突变 IspH 蛋白的晶体结构揭示了催化过程中底物羟甲基基团的旋转。
J Mol Biol. 2012 Feb 10;416(1):1-9. doi: 10.1016/j.jmb.2011.11.033. Epub 2011 Nov 23.
8
Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.异戊二烯单元的生物合成：LytB/IspH酶的[4Fe-4S]簇与底物和抑制剂结合的穆斯堡尔光谱
Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11976-9. doi: 10.1002/anie.201104562. Epub 2011 Oct 19.
9
Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues.使用氟取代的底物类似物研究异戊烯焦磷酸合酶（IPP 合酶），一种甲基赤藓醇磷酸途径中的关键酶。
Org Lett. 2011 Nov 4;13(21):5912-5. doi: 10.1021/ol202559r. Epub 2011 Oct 7.
10
Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms.Fe(4)S(4)- 簇蛋白 IspH（LytB）的抑制作用：电子顺磁共振、金属环和机制。
J Am Chem Soc. 2010 May 19;132(19):6719-27. doi: 10.1021/ja909664j.
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